Contents

Contents

• Perspective

  • Neuronal Polarity and the Kinesin Superfamily Proteins

    By Takao Nakata, Nobutaka Hirokawa

    Science's STKE06 Feb 2007 : pe6 Full AccessRestricted Access

    Kinesins transport proteins and lipids necessary for neuronal process specification and maturation.

    • Abstract
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• Editors' Choice

  • Diversifying Role for β-Arrestin

    By L. Bryan Ray

    Science's STKE06 Feb 2007 : tw41 Full AccessRestricted Access

    A regulatory protein that limits the extent of signaling through a well-described class of receptor performs the same function for another receptor class, but by a completely different mechanism.

    • Abstract

  • Mitochondrial Diversion and Aging

    By L. Bryan Ray

    Science's STKE06 Feb 2007 : tw42 Full AccessRestricted Access

    A protein that prolongs life span when mutated has oxidoreductase activity in mitochondria where it generates toxic oxygen radicals, suggesting a possible therapeutic target.

    • Abstract

  • Good and Bad Products of Calpain Cleavage

    By Nancy R. Gough

    Science's STKE06 Feb 2007 : tw43 Full AccessRestricted Access

    NMDA receptor activation triggers calpain-mediated cleavage of metabotropic glutamate receptors and β-catenin.

    • Abstract

  • Why the Taste of Some Spicy Foods Lingers

    By Nancy R. Gough

    Science's STKE06 Feb 2007 : tw44 Full AccessRestricted Access

    Some chemicals that activate TRPA1 channels do so by covalently modifying cysteine residues.

    • Abstract

  • Maintaining a Barrier

    By Elizabeth M. Adler

    Science's STKE06 Feb 2007 : tw45 Full AccessRestricted Access

    Dual oxidase 1 plays a key role in repair of airway epithelium.

    • Abstract

  • MicroRNA May Link Inflammation and Cancer

    By L. Bryan Ray

    Science's STKE06 Feb 2007 : tw46 Full AccessRestricted Access

    A microRNA previously identified as an oncogene mediates inflammatory responses to viral infection.

    • Abstract