Editors' ChoiceReceptors

A Receptor for Vitamin A Uptake

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Science's STKE  13 Feb 2007:
Vol. 2007, Issue 373, pp. tw55
DOI: 10.1126/stke.3732007tw55

Vitamin A has a large number of biological functions, including roles in vision, reproduction, immunity, tissue regeneration, and neuronal signaling. The existence of a cell surface receptor for the vitamin A carrier retinol binding protein (RBP) was proposed more than 30 years ago. Kawaguchi et al. now report the identification and characterization of the long-sought RBP receptor. The RBP receptor is a multipass-transmembrane domain protein with robust RBP binding and vitamin A uptake activity and is localized to the expected cellular locations for vitamin A uptake.

R. Kawaguchi, J. Yu, J. Honda, J. Hu, J. Whitelegge, P. Ping, P. Wiita, D. Bok, H. Sun, A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 315, 820-825 (2007). [Abstract] [Full Text]

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