20 February 2007
Vol 2007, Issue 374
  • Contents

    • Meeting Report

    • Editors' Choice

      • Inhibiting or Enhancing Release?

        Opposing effects of K+ channels on neuropeptide release may contribute to its activity dependence.

      • The Queen of Dopamine

        Queen bees may influence workers with a dopamine-like pheromone.

      • And Then There Were Three

        Stem cell daughters in the Drosophila intestine can take on one of three identities; this choice is controlled by the activation level of a common developmental receptor.

      • Lethal Injection

        A family of virulence factors in bacteria removes a phosphate from a key signaling enzyme in its infected host and thereby interferes with the host's innate immunity.

      • Joint Effort

        A mouse version of rheumatoid arthritis can be ameliorated by inhibition or elimination of a cell surface adhesion molecule found within joints, suggesting a therapeutic approach for humans.

      • Sticky Fingers

        In motile cells, actin fibers form integrin-covered protrusions that are poised to interact with surfaces in the cell's search for adhesion sites.

About The Cover

Cover image expansion

COVER This week features a Meeting Report on research into tyrosine kinase inhibitors as therapeutic tools against cancer. The image alludes to the blossoming of kinase inhibitor research over the past 20 years, with each "blossom" represented by the structure of a kinase for which an inhibitor is known. [Image: Christopher Bickel, AAAS]