Customizing MicroRNAs

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Science's STKE  27 Feb 2007:
Vol. 2007, Issue 375, pp. tw65
DOI: 10.1126/stke.3752007tw65

MicroRNAs (miRNAs) are ubiquitous small noncoding RNAs that regulate gene expression in eukaryotes. Because of the double-stranded nature of intermediates in their synthesis, miRNAs are potential targets for RNA editing. Kawahara et al. now show that members of a related mammalian miRNA cluster are edited in their seed regions, the region that determines their target specificity. The editing, which is tissue specific, changes the potential target range of the miRNAs.

Y. Kawahara, B. Zinshteyn, P. Sethupathy, H. Iizasa, A. G. Hatzigeorgiou, K. Nishikura, Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315, 1137-1140 (2007). [Abstract] [Full Text]

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