06 March 2007
Vol 2007, Issue 376
  • Contents

    • Perspective

      • Understandable Complexity

        The book "An Introduction to Systems Biology" offers a look at the design principles of biological control circuits.

    • Editors' Choice

      • Signaling the Way Home

        Dendritic cells convert vitamin D3 into the active form and thereby direct T cell homing to skin.

      • Caspase for Cell Movement

        Caspase 11 promotes cell migration by participating in regulation of actin dynamics.

      • Variation on Synaptic Potentiation

        In an unusual form of plasticity, certain synapses in rat interneurons are strengthened if presynaptic activity occurs while the postsynaptic cell is at rest or hyperpolarized.

      • The Heart of Metabolic Syndrome?

        A mutation in a key signaling pathway causes both coronary artery disease and a metabolic syndrome, explaining why these disorders are often associated with one another.

      • Drugs, Dopamine, and Disposition

        Rats that tend to abuse cocaine have lower dopamine receptor availability even before drug exposure, suggesting that this trait is preexisting and not a result of drug abuse.

      • MAPK Cascade in Stomatal Specification

        A mitogen-activated protein kinase cascade appears critical to maintaining the one-cell spacing of stomata in plant leaves.

      • Interfering with Interferon

        A kinase activated in response to viral infection unexpectedly acts directly on a transcription factor for antiviral genes.

About The Cover

Cover image expansion

COVER This week features a Book Review of "An Introduction to Systems Biology" by Uri Alon. The image represents favored (dark) feed forward loops in the transcriptional networks of yeast and E. coli over a background of unfavored loops. [Image: Christopher Bickel, AAAS]