13 March 2007
Vol 2007, Issue 377
  • Contents

    • Perspective

    • Review

    • Editors' Choice

      • How Smurfs Control Axon Formation

        Proteolytic degradation of the GTPase Rap1B is required to specify formation of a single axon from multiple developing neurites.

      • Releasing ErbB4

        Trophinin-mediated cell adhesion may enable ErbB4 activation to stimulate trophoblast proliferation and motility.

      • Eat Up to Meet Up

        An unexpected function of autophagy (cellular self-digestion) is to unite RNA from infecting viruses with immune recognition molecules to trigger innate immune defenses.

      • Regulating Calcium in Plants

        An interplay of signaling pathways monitors and controls the diurnal rhythm in intracellular calcium in plant cells, responding to soil calcium levels and transpiration.

      • Checkpoint, What Checkpoint?

        Unexpectedly, yeast--a widely used organism for cell cycle studies--does not have a mechanism to prevent cell division if DNA replication is still incomplete.

      • Changing the Histone Landscape

        Regions of chromatin that are epigenetically silenced and highly regulated are coated with histones that rapidly bind and release the DNA.

About The Cover

Cover image expansion

COVER This week features a Perspective on focal adhesions, protein complexes that link the cell interior to the extracellular matrix. The image illustrates a model of focal adhesion proteins functioning as a molecular clutch. [Image: Yu-Li Wang, University of Massachusetts Medical School]