Contents
Vol 2007, Issue 379
Contents
Perspective
- Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death
Phagocytic NADPH oxidase contributes to various neutrophil processes including the formation of neutrophil extracellular traps (NETs).
Editors' Choice
- Better Without Bax?
Preserving ovarian function may improve the health of aging female mice.
- The Trouble with Having a Big Heart
The tumor suppressor p53 induces cardiac dysfunction through the inhibition of angiogenesis.
- Making a New Tail
The H+ pump and membrane voltage play crucial roles in Xenopus tail regeneration.
- Does Actin Give the Nod2 to NF-κB Activation?
Association of Nod2 with cytoskeletal structures may represent a sequestration mechanism that allows its ready mobilization to activate NF-κB.
- Removing Ubiquitin to Regulate NF-κB Activity
A deubiquitinylase component of the COP9 signalosome stabilizes IκΒα, thereby regulating NF-κB activation.
- IL-2 Antagonizes Th17 Differentiation
The cytokine formerly known as T cell growth factor appears to attenuate the differentiation of T helper 17 (Th17) cells.
- Division Decisions
Upon antigen binding, immune cells generate pathogen-fighting cells from daughters arising close to the antigen and memory cells from daughters away from it.
- Making Bone with Oxysterols
Activation of the Hedgehog pathway is one way oxysterols promote osteoblast differentiation.
- Plant Hormone Signaling Receptor
The cell surface receptor for an important growth regulator in plants binds to its ligand with high affinity and activates downstream targets.
- Calpain Cleaves a Memory Inhibitor
SCOP cleavage by calpain allows activation of mitogen-activated protein kinases and gene expression that promotes memory formation.
- Modeling Competence
A genetic circuit for bacterial cell differentiation exhibits a surprisingly varied repertoire of dynamic responses that depend on the amount of noise in the component biochemical reactions.
- Staying in Charge
The crystal structure of a key metabolic regulator reveals how it senses the ratio of ATP to AMP, initiating feedback processes to optimize ATP levels in the cell.
