Contents
Vol 2007, Issue 380
Contents
Perspective
- Fat Flies Expanded the Hippo Pathway: A Matter of Size Control
An atypical cadherin contributes to organ size in Drosophila.
Teaching Resource
- Molecular Animation of Cell Death Mediated by the Fas Pathway
Using the published structures, this movie provides a unique view of the molecular events associated with apoptosis induced by the prototypic death receptor Fas.
Editors' Choice
- Those Anxious Adolescents
Reversal of the effects of neurosteroids in the hippocampus at puberty may underlie the highly emotional responses of teens.
- Pollution Disrupts Endocrine Signaling
The aryl hydrocarbon receptor that binds the environmental pollutant dioxin forms an E3 ubiquitin ligase complex that promotes the degradation of steroid receptors.
- A Volatile Response to Injury
Volatile organic compounds appear to act as an intraplant defense signal.
- STAT3 Regulates the Generation of Th17 Cells
STAT3 has an essential role in regulating the cytokine signals needed to generate Th17 cells.
- Epithelia Control Gut Inflammation
Without NF-κB signaling in the epithelial cells of the intestine, animals are prone to infection and intestinal inflammation.
- Is Suppressor Function in Mouse CD4+CD25+ Tregs Due Wholly to GRAIL?
The E3 ubiquitin ligase, GRAIL, previously associated with anergic T cells, is expressed in mouse CD4+CD25+ Tregs and induces suppressor function in vitro.
- ASKing Macrophages to Promote Hair Growth
The recruitment and activation of macrophages appears to play a critical role in promoting post-injury hair growth.
- Key to Liver Regeneration
A receptor for a factor that supports survival of neuronal cells is unexpectedly also required for liver regeneration after damage.
- Two Ways to Segment an Insect
Even though the head-tail axes of wasps and fruit flies develop similarly, they use two entirely different molecular mechanisms.
- Targeting Transmembrane Domains
Synthetic peptides can be designed to bind with high affinity and specificity to the regions of membrane proteins that span the lipid bilayer of the cell.
