Contents
Vol 2007, Issue 381
Contents
Editorial Guide
- Focus Issue: Exploring New Avenues for Cancer Treatment
Recent research on cancer cell pathophysiology provides reasons to be hopeful about development of novel therapies.
Perspective
- Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?
Could targeted therapies directed against aerobic metabolism represent a viable approach to treating cancer?
Review
- Sequestration and Segregation of Receptor Kinases in Epithelial Cells: Implications for ErbB2 Oncogenesis
Can oncogenesis occur by co-opting normal physiological responses to epithelial damage?
Meeting Report
- Meeting Report: Tumor Biology--How Signaling Processes Translate to Therapy
The most recent meeting of the Signal Transduction Society highlighted the translation of signaling research into advances in the cancer clinic.
Editors' Choice
- Sensing Salt, Sending Signals
Glial cells in the brain sense Na+ concentrations and signal through lactate secretion to neighboring neurons.
- Understanding Inositol Pyrophosphates
A yeast enzyme is identified that synthesizes the inositol pyrophosphate IP6.
- Receptors Respond to Metabolic Flux
Glycosylation of growth factor receptors controls their duration at the cell surface and may explain the proliferative versus growth-arresting responses to these receptors.
- Golgi Releases a Numb Regulator
Release of ACBD3 by Golgi fragmentation during mitosis may provide a mechanism for coupling Numb functions to the cell cycle.
- Using Cysteine to Set the Stage for Its Own Degradation
Degradation of the Ubc7 E2 ubiquitin ligase depends on autoubiquitination on a cysteine residue.
- Ubiquitination of Estrogen Receptor α by BRCA1
Regulation of estrogen receptor α activity may occur through the ubiquitin ligase activity of BRCA1.
- The Mechanism of Action of the Tumor Suppressor HRSL3
The tumor suppressor HRSL3 induces apoptosis in an ovarian cancer cell line by inhibiting protein phosphatase 2A activity.
- Inhibition of IL-13 Signaling in Bronchial Epithelial Cells by LPA
Lysophosphatidic acid-mediated inhibition of interleukin-13 signaling could modulate airway responsiveness in asthma.
- Sizing Up Man’s Best Friend
Small dogs are small because they carry a particular allele of the gene encoding insulin-like growth factor 1.
