Contents
Vol 2007, Issue 382
Contents
Perspective
- Regulation of PC12 Cell Differentiation by cAMP Signaling to ERK Independent of PKA: Do All the Connections Add Up?
What is the PKA-independent path from cAMP to ERK?
Editors' Choice
- Adult Organ Growth
Growth of the liver and pancreas in adults does not appear to be a reactivation of developmental programs.
- Pancreatic β Cell Proliferation Is Stimulated by Wnt Signaling
Stimulation of pancreatic islet cultures with Wnt3a results in increased β cell proliferation and insulin production.
- Dual Lipid Pathways for Migration
Studies of Dictyostelium discoideum reveal a parallel pathway for chemotaxis involving phospholipase A2 and derivatives of arachidonic acid.
- Making Life or Death Choices with CBP
CBP phosphorylation by IKKα may be critical to the choice between proliferation and apoptosis.
- Enabling Endocrine Action of Fibroblast Growth Factors
Structural studies of endocrine-acting fibroblast growth factors may explain their unusual biological properties.
- The M3-Muscarinic Receptor Is Phosphorylated and Regulated by Casein Kinase 2
Phosphorylation of the M3-muscarinic receptor by kinases occurs in a cell-specific fashion and leads to different signaling outcomes.
- Double Source for S1P
Immune cells move into the bloodstream in response to a lipid signal made in red blood cells and move into the lymphatic system when the same signal is made elsewhere.
- Making LIGHT of Lipid Metabolism
Lipid levels in the blood, which are deregulated in atherosclerosis, are in part controlled by immune cells in the liver, suggesting a therapeutic target.
- Spotlight on the Pre-B Cell Receptor
The structure of receptors on developing immune cells may explain how the cells acquire specificity for certain antigens and indicate that signaling occurs by oligomerization.
