Contents
Vol 2007, Issue 383
Contents
Editorial Guide
- Focus Issue: From Egg to Egg—Cell Signaling in Germ Cells
Signals from the surrounding tissues control survival and migration of germ cells.
Perspectives
- What Is Left Behind—Quality Control in Germ Cell Migration
Fly and mouse use different molecules but similar mechanisms to guide migration of primordial germ cells and eliminate those that fail to migrate.
- Pollen-Pistil Signaling in Self-Incompatible Poppy: Does It Allow More Efficient Resource Allocation in the Pistil?
Destruction of incompatible pollen tubes may leave more resources available for supporting the growth of compatible ones.
Editors' Choice
- Reversing the Signal to Stimulate Insulin Secretion
Forward signaling downstream of Eph inhibits insulin signaling, whereas reverse signaling downstream of ephrin signaling stimulates insulin secretion.
- Pathological Effects of Too Much or Too Little MicroRNA
During development, too little miR-1-2 leads to sudden death, and in the adult too much miR-1 leads to arrhythmias following heart attacks.
- IFN-α Finds Its SOCS
IFN-α treatment of T cells from patients with metastatic melanoma stimulates the production of suppressor of cytokine signaling (SOCS) proteins.
- Does D2 Determine DAT Location?
The D2 dopamine receptor may enhance dopamine transporter activity through direct protein interactions.
- The Winners Recall Memories
During formation of a memory in a fearful situation, rat neurons with higher amounts of the transcription factor CREB are recruited for selective enhancement.
- Adjusting Synaptic Plasticity
New insights clarify signaling events that underlie integration of auditory and somatosensory input in the brain.
- That’s Far Enough
A diffusible transcription factor specifies a layer exactly one cell thick in plant root tips because as it enters a cell, it is restrained permanently by a binding protein.
- Giving ITK the SLP
A continuous interaction between SLP-76 and the kinase ITK is necessary to mediate and maintain the activity of ITK.
