Contents
Vol 2007, Issue 384
Contents
Editorial Guide
- Focus Issue: Keeping the Immune Response in Check
Switching off the immune response is as important as switching it on.
Perspectives
- Professional and Part-Time Chemokine Decoys in the Resolution of Inflammation
Chemokine receptors that mediate the cellular infiltration that causes inflammation can then change hats and help to bring about resolution.
- Striking Back at the Activator: How IκB Kinase Terminates Antigen Receptor Responses
The scaffold involved in activating NF-κB also plays a role in terminating the response.
- Regulation of Interferon Production by RIG-I and LGP2: A Lesson in Self-Control
Interactions in cis and trans control the activity of CARD-domain proteins involved in regulating immune responses.
- CARD-Bcl10-Malt1 Signalosomes: Missing Link to NF-κB
Signaling complexes using different CARD scaffolds, as well as Bcl10 and Malt1, link receptors in various cells to NF-κB.
Editors' Choice
- Differential Responses to Change
In maintaining metabolic homeostasis, bacteria respond to genetic disruptions with large changes in metabolites but to environmental disturbance with changes in enzyme levels.
- Turned On by a Low pH
The PhoQ protein kinase acts as a pH sensor and is directly activated by acidic pH.
- GPCR Versus Cytokine Receptor: Is One As Good As the Other?
Sphingosine 1-phosphate (S1P), acting through its G protein-coupled receptor S1P1, can substitute for IL-23 in the development of Th17 cells.
- Interacting at the ER
An interaction between the endoplasmic reticular protein UNC93B and Toll-like receptors TLR3, TLR7, and TLR9 is important for responding to infection.
- Serotonin’s Axon Guidance Switch
Signals initiated by the neurotransmitter serotonin can reverse neuronal responses to axon guidance cues.
- Enlisting ERK5 and NF-κB in the G2 to M Transition
The kinase ERK5, acting through the kinase RSK2, activates NF-κB to promote the expression of genes necessary for progression through mitosis.
- Micromanaging the Immune System
Deletion of a microRNA sequence in mice impairs their immunity, causing abnormal immune responses and cytokine production, as well as gut and lung inflammation.
- The Heart of Stress Responses
A microRNA coded within an intron of a myosin gene increases the pathological expression of embryonic myosin after stress.
- An Antigenic Route Planner
When immune cells process foreign antigen via the endosomes, effector T cells are stimulated, whereas antigen processed by lysosomes activates helper T cells.
- Life Without Dynamin
A small regulatory protein is required for recycling of synaptic vesicles during high-frequency neuronal activity, but an independent mechanism maintains basal recycling.
