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Abstract
When exploring control of a biological system such as the inflammatory response, we often think first of mechanisms that promote activation of the system. But just as important are the signals that that modulate and terminate these processes. Unchecked recruitment and infiltration of leukocytes into tissues and the unrestrained production of pro-inflammatory cytokines and chemokines can lead to tissue damage and even cancer. This issue of Science’s STKE highlights studies that enhance our understanding of how pro-inflammatory signals are switched on, and--equally important--how they are switched off.
