Contents
Vol 2007, Issue 386
Contents
Perspectives
- Extrasynaptic NMDA Receptors Reshape Gene Ranks
Activation of synaptic or extrasynaptic NMDARs produces different gene expression profiles, which may explain their distinct roles in neuronal survival and death, respectively.
- The Regulation of Nuclear Membrane Permeability by Ca2+ Signaling: A Tightly Regulated Pore or a Floodgate?
Do calcium signals lead to specific or nonspecific increases in the permeability of the nuclear pore complex?
Editors' Choice
- Regaining the Lost Past
A histone deacetylase inhibitor enabled the recovery of lost memories in a mouse model of neurodegenerative disease.
- Linking Inflammation and Metabolism
A membrane protein functions in coupling metabolism to inflammatory responses like those seen in metabolic diseases such as obesity and diabetes.
- Maintaining Polarity in the Face of Energetic Stress
In Drosophila, the adenosine monophosphate-regulated kinase AMPK contributes to epithelial polarity under conditions of energy depletion.
- Sharing the PDGF Receptor
Cells lacking VEGF receptors use PDGF receptors to respond to VEGF.
- β-catenin Activates ERK: Two Pathways for the Price of One
Wnt/β-catenin signaling stimulates extracellular signal-regulated kinase (ERK) pathways through effects on Ras.
- IP4 Recruits Signaling Proteins
A kinase phosphorylates the inositol pyrophosphate IP3 to generate IP4 and is necessary for cell signaling during positive selection of immune cells.
- Masterful Decisions
Developing immune cells become antibody-producing cells through activation of a proto-oncogene that inhibits the alternative developmental pathway.
