Contents
Vol 2007, Issue 387
Contents
Perspectives
- Micromanagement During the Innate Immune Response
MicroRNAs induced by pro-inflammatory mediators may provide a link between inflammation and cancer.
- Book Review: Plant Gene Expression
The book "Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing" describes how structural differences in RNA transcripts can affect gene expression in plants.
Editors' Choice
- Decisions of Life or Death for Retinoic Acid
The key to whether the hormone retinoic acid promotes proliferation and survival or differentiation and cell death lies with binding proteins that shuttle the hormone to distinct receptors.
- Synaptic Sumoylation
Sumoylation promotes agonist-dependent endocytosis of the kainate receptor, thereby modifying synaptic transmission.
- TGF-β1 Uses Semaphorin
The semaphorin, SEMA7A, mediates the effects of TGF-β1 in lung fibrosis.
- Regenerating Hair Follicles
Wnt signaling promotes hair follicle regeneration in response to injury.
- Tumor Suppressor Joined to Wnt Network
Analysis of a protein interaction network reveals that a newly identified tumor suppressor for pediatric kidney cancer is part of an important developmental signaling cascade.
- Pseudopodial Proteome
Global proteomic and phosphoproteomic analysis of the cell body and the pseudopod of migrating cells reveal different networks.
- From Leaf to Flower
The protein products of the genes Hd3a in rice and FT in Arabidopsis are the elusive florigen signals that move from leaf to shoot to induce flowering.
- Smart Drugs, Smarter Tumors
Human lung cancers can become resistant to a kinase inhibitor by producing multiple copies of a gene in the same pathway, bypassing the inhibited step.
- Seeing the Light
When a flavin-based photoreceptor absorbs a photon, large-scale conformational changes at the protein N terminus initiate functional changes.
