22 May 2007
Vol 2007, Issue 387
  • Contents

    • Perspectives

    • Editors' Choice

      • Decisions of Life or Death for Retinoic Acid

        The key to whether the hormone retinoic acid promotes proliferation and survival or differentiation and cell death lies with binding proteins that shuttle the hormone to distinct receptors.

      • Synaptic Sumoylation

        Sumoylation promotes agonist-dependent endocytosis of the kainate receptor, thereby modifying synaptic transmission.

      • TGF-β1 Uses Semaphorin

        The semaphorin, SEMA7A, mediates the effects of TGF-β1 in lung fibrosis.

      • Glial Fiber Optics

        Specialized glial cells transmit light to the retina.

      • Regenerating Hair Follicles

        Wnt signaling promotes hair follicle regeneration in response to injury.

      • Tumor Suppressor Joined to Wnt Network

        Analysis of a protein interaction network reveals that a newly identified tumor suppressor for pediatric kidney cancer is part of an important developmental signaling cascade.

      • Pseudopodial Proteome

        Global proteomic and phosphoproteomic analysis of the cell body and the pseudopod of migrating cells reveal different networks.

      • From Leaf to Flower

        The protein products of the genes Hd3a in rice and FT in Arabidopsis are the elusive florigen signals that move from leaf to shoot to induce flowering.

      • Smart Drugs, Smarter Tumors

        Human lung cancers can become resistant to a kinase inhibitor by producing multiple copies of a gene in the same pathway, bypassing the inhibited step.

      • Seeing the Light

        When a flavin-based photoreceptor absorbs a photon, large-scale conformational changes at the protein N terminus initiate functional changes.

About The Cover

Cover image expansion

COVER This week features a Book Review of Regulation of Gene Expression in Plants: The Role of Transcript Structure and Processing, edited by Carole L. Bassett. The image depicts maize with stripes resulting from the movement of transposons. [Image: Alan Rose, University of California, Davis]