Contents
Vol 2007, Issue 389
Contents
Perspective
- The Biology of Regenerative Medicine
Can regenerative biology and regenerative medicine grow together into a single disicpline?
Protocol
- High-Sensitivity Detection and Quantitative Analysis of Native Protein-Protein Interactions and Multiprotein Complexes by Flow Cytometry
Protein interactions can be quantitatively assessed using capture beads and flow cytometry in either a high-throughput or low-throughput format.
Editors' Choice
- Silencing Cell Death?
A decrease in DAPK1 activity may enhance susceptibility to chronic lymphocytic leukemia.
- E-Cadherin Inhibits the Growth of Single Cells
The inhibition of cell growth and epidermal growth factor receptor signaling by E-cadherin ligation does not require cell-cell contact.
- Shore Up That Wall!
Phosphorylation of the enzyme that produces UDP-glucose redirects synthesis to the cell periphery to increase wall glucan synthesis at the expense of glycogen synthesis.
- Tumor Necrosis Factor Member Promotes Sustained Toll-Like Receptor Signaling
TNF-like protein 4-1BBL may interact with TLRs to mediate sustained production of inflammatory cytokines by macrophages.
- Diet of Worms
The longevity of C. elegans induced by a restrictive diet is mediated by the transcription factors PHA-4 and SKN-1.
- Transcriptional Response to Nod Signaling
The DNA binding transcription factor ERN is necessary for nodulation.
- Not Like Peas in a Pod
Two species of nitrogen-fixing bacteria lack the usual liposaccharide signal by which they communicate with their legume hosts and instead may use a purine derivative.
- Let the RNA Do Its Business
An abundant viral RNA stabilizes host mitochondria and thus prevents infection-induced cell death, ensuring that the host cell survives long enough for the virus to reproduce.
- Designer Proteasome
A proteasome found only in cortical epithelial cells of the thymus has a specific protein-cleaving subunit that may contribute to positive selection of developing immune cells.
