12 June 2007
Vol 2007, Issue 390
  • Contents

    • Perspectives

    • Editors' Choice

      • Watching Your Weight with Retinaldehyde?

        The vitamin A metabolite retinaldehyde plays a distinct role in inhibiting adipogenesis and in mediating the metabolic response to diet.

      • Pulled in the Wrong Direction

        Guidance receptor signaling to border cells provides migrational directionality by inhibiting the extension of inappropriate protrusions.

      • Dendrites Are Only a CLICK Away

        The Ca2+/calmodulin-dependent protein kinase CL3 is targeted to lipid rafts, where it promotes the outgrowth of dendrites.

      • From Receptor to Ras Through Phosphatidic Acid

        Receptor tyrosine kinases and T cell receptor co-receptors activate Ras at the plasma membrane through the production of phosphatidic acid by phospholipase D2.

      • Phospholipid Minds the Gap (Junction)

        Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits conductance of gap junction channels.

      • Release from the ER

        The G1 cyclin Cln3 in budding yeast is released from the endoplasmic reticulum to accumulate in the nucleus as chaperones become available.

      • Allergy-Blocking Transmitters

        Endogenous cannabinoids released from neurons usually inhibit allergic skin responses; in mice in which they are absent, allergic reactions are exacerbated.

      • Target Identification Tool

        Chromatin immunoprecipitation and high-throughput sequencing identify the nearly 2000 specific DNA binding sites for a neuronal transcription factor.