Contents
Vol 2007, Issue 390
Contents
Perspectives
- IL-33: A Sheep in Wolf’s Clothing?
IL-33 joins the exclusive group of cytokines with nuclear as well as receptor-mediated functions.
- In SYNC: The Ins and Outs of Circadian Oscillations in Calcium
A slow oscillation in cytoplasmic calcium may function in circadian signaling.
Editors' Choice
- Watching Your Weight with Retinaldehyde?
The vitamin A metabolite retinaldehyde plays a distinct role in inhibiting adipogenesis and in mediating the metabolic response to diet.
- Short Days and Estrogen Make for Short Tempers
The effect of estrogen on aggression in mice depends on the season.
- Pulled in the Wrong Direction
Guidance receptor signaling to border cells provides migrational directionality by inhibiting the extension of inappropriate protrusions.
- Dendrites Are Only a CLICK Away
The Ca2+/calmodulin-dependent protein kinase CL3 is targeted to lipid rafts, where it promotes the outgrowth of dendrites.
- From Receptor to Ras Through Phosphatidic Acid
Receptor tyrosine kinases and T cell receptor co-receptors activate Ras at the plasma membrane through the production of phosphatidic acid by phospholipase D2.
- Phospholipid Minds the Gap (Junction)
Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits conductance of gap junction channels.
- Release from the ER
The G1 cyclin Cln3 in budding yeast is released from the endoplasmic reticulum to accumulate in the nucleus as chaperones become available.
- Allergy-Blocking Transmitters
Endogenous cannabinoids released from neurons usually inhibit allergic skin responses; in mice in which they are absent, allergic reactions are exacerbated.
- Target Identification Tool
Chromatin immunoprecipitation and high-throughput sequencing identify the nearly 2000 specific DNA binding sites for a neuronal transcription factor.
