Contents
Vol 2007, Issue 391
Contents
Perspectives
- Double Duty for Rac1 in Epidermal Wound Healing
Rac1 has roles in promoting both the proliferation and migration of keratinocytes during wound healing.
- BRCA1 Control of Steroid Receptor Ubiquitination
Ubiquitination of the estrogen receptor by BRCA1 complex links the ubiquitin ligase activity of BRCA1 to its role as a tissue-specific tumor suppressor.
Editors' Choice
- Identifying Oncogenes
IKBKE is a breast cancer oncogene that may link PI3K signaling to activation of the NF-κB pathway.
- Selective Killing
Erastin leads to mitochondrial-mediated nonapoptotic death in cells with activating mutations of Ras.
- Stimulating Neurogenesis to Treat Alzheimer's Disease
Injection of granulocyte colony-stimulating factor restores cognitive function in mouse models of Alzheimer's disease.
- Influenced by the Wrong Crowd
Abnormalities in the hematopoietic stem cell microenvironment can lead to disorders of myeloproliferation.
- The Nuclear Option
The Drosophila homolog of the phosphatidylserine receptor is localized to the nucleus and protects against apoptosis.
- Signaling Central
Large, ribosome-sized protein complexes containing receptor and adaptor proteins assemble at cell membranes to detect and transduce a critical developmental signal.
- Tuning Immune Stimulation
Mechanistic understanding of how ligands can fine-tune the immune response may lead to better vaccine adjuvants.
- Hans Brinker Meets Gap Junctions
Structural studies reveal a plug in the pore of gap junction hemichannels that form intercellular links.
- From Klotho to Calcium
A protein with several reported functions may also influence calcium metabolism by modulating the abundance of the sodium-potassium pump at the plasma membrane.
- Bone Morphogenetic Protein Clips Angiogenic Role of Prolactin
Cleavage by the protease BMP-1 converts prolactin from an angiogenic factor to an antiangiogenic one.
Erratum