Contents

Contents

• Perspectives

  • Double Duty for Rac1 in Epidermal Wound Healing

    By C. Michael DiPersio

    Science's STKE19 Jun 2007 : pe33 Full AccessRestricted Access

    Rac1 has roles in promoting both the proliferation and migration of keratinocytes during wound healing.

    • Abstract
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  • BRCA1 Control of Steroid Receptor Ubiquitination

    By George F. Heine, Jeffrey D. Parvin

    Science's STKE19 Jun 2007 : pe34 Full AccessRestricted Access

    Ubiquitination of the estrogen receptor by BRCA1 complex links the ubiquitin ligase activity of BRCA1 to its role as a tissue-specific tumor suppressor.

    • Abstract
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• Editors' Choice

  • Identifying Oncogenes

    By Elizabeth M. Adler

    Science's STKE19 Jun 2007 : tw211 Full AccessRestricted Access

    IKBKE is a breast cancer oncogene that may link PI3K signaling to activation of the NF-κB pathway.

    • Abstract

  • Selective Killing

    By John F. Foley

    Science's STKE19 Jun 2007 : tw212 Full AccessRestricted Access

    Erastin leads to mitochondrial-mediated nonapoptotic death in cells with activating mutations of Ras.

    • Abstract

  • Stimulating Neurogenesis to Treat Alzheimer's Disease

    By Nancy R. Gough

    Science's STKE19 Jun 2007 : tw213 Full AccessRestricted Access

    Injection of granulocyte colony-stimulating factor restores cognitive function in mouse models of Alzheimer's disease.

    • Abstract

  • Influenced by the Wrong Crowd

    By Elizabeth M. Adler

    Science's STKE19 Jun 2007 : tw214 Full AccessRestricted Access

    Abnormalities in the hematopoietic stem cell microenvironment can lead to disorders of myeloproliferation.

    • Abstract

  • The Nuclear Option

    By John F. Foley

    Science's STKE19 Jun 2007 : tw215 Full AccessRestricted Access

    The Drosophila homolog of the phosphatidylserine receptor is localized to the nucleus and protects against apoptosis.

    • Abstract

  • Signaling Central

    By Beverly Purnell

    Science's STKE19 Jun 2007 : tw216 Full AccessRestricted Access

    Large, ribosome-sized protein complexes containing receptor and adaptor proteins assemble at cell membranes to detect and transduce a critical developmental signal.

    • Abstract

  • Heating Up Circadian Rhythms

    By Nancy R. Gough

    Science's STKE19 Jun 2007 : tw217 Full AccessRestricted Access

    The light sensor CRY also responds to changes in temperature.

    • Abstract

  • Tuning Immune Stimulation

    By Stephen J. Simpson, Valda Vinson

    Science's STKE19 Jun 2007 : tw218 Full AccessRestricted Access

    Mechanistic understanding of how ligands can fine-tune the immune response may lead to better vaccine adjuvants.

    • Abstract

  • Hans Brinker Meets Gap Junctions

    By L. Bryan Ray

    Science's STKE19 Jun 2007 : tw219 Full AccessRestricted Access

    Structural studies reveal a plug in the pore of gap junction hemichannels that form intercellular links.

    • Abstract

  • From Klotho to Calcium

    By L. Bryan Ray

    Science's STKE19 Jun 2007 : tw220 Full AccessRestricted Access

    A protein with several reported functions may also influence calcium metabolism by modulating the abundance of the sodium-potassium pump at the plasma membrane.

    • Abstract

  • Bone Morphogenetic Protein Clips Angiogenic Role of Prolactin

    By L. Bryan Ray

    Science's STKE19 Jun 2007 : tw221 Full AccessRestricted Access

    Cleavage by the protease BMP-1 converts prolactin from an angiogenic factor to an antiangiogenic one.

    • Abstract

• Erratum

  • A Correction to the Protocol Titled "High-Sensitivity Detection and Quantitative Analysis of Native Protein-Protein Interactions and Multiprotein Complexes by Flow Cytometry" by A. G. Schrum et al.

    Science's STKE19 Jun 2007 : er3 Full AccessRestricted Access

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