26 June 2007
Vol 2007, Issue 392
  • Contents

    • Perspective

    • Protocol

    • Editors' Choice

      • Actin to Safeguard Transcription

        In cultured cells, serum regulates the interaction of nuclear actin with a transcriptional coactivator, facilitating its nuclear transport and thus stimulating gene expression.

      • Channeling a Metabolic Message

        Fluctuations in cytoplasmic pyruvate concentration may directly link energy metabolism to the regulation of calcium influx.

      • A New Role for Ankyrin Repeats

        An ATP-binding site in its ankyrin repeat domain modulates the activity of the ion channel TRPV1.

      • Cathepsin S's Cuts Cause Pain

        The cathepsin S protease is implicated in generation of chronic pain by releasing a cytokine.

      • Scar Formation

        The p75 neurotrophin contributes to tissue scarring by inhibiting plasminogen activity responsible for fibrin degradation.

      • Morphology Central

        A large genetic screen and automated characterization of cell morphology allowed mapping of the pathways controlling cell adhesion and membrane protrusion and tension.

      • Tropical Disease Vector Genome

        The genome of the mosquito that carries dengue and yellow fever consists of almost 50 percent transposable elements and more than 15,000 protein-coding genes.

About The Cover

Cover image expansion

COVER This week features a Perspective on pathways through which GPCRs signal to nonreceptor tyrosine kinases. The image depicts a seven-transmembrane receptor. [Image: Christopher Bickel, AAAS]