Contents
Vol 2007, Issue 393
Contents
Perspectives
- Foxp3 Is Required Throughout the Life of a Regulatory T Cell
The transcription factor Foxp3 is needed for both the generation and maintenance of regulatory T cells.
- The Surprising Catch of a Voltage-Gated Potassium Channel in a Neuronal SNARE
Phosphorylation of the Kv2.1 potassium channel may allow it to affect vesicle release in different ways.
Editors' Choice
- FOXP3 Is an X-Linked Tumor Suppressor
FOXP3 is a tumor suppressor that inhibits ERBB2 expression.
- NetworKIN Depends on What You Do, Where You Are, and Who You Know
Contextual information facilitates modeling in vivo phosphorylation networks.
- Targeting CREB's Activity
Transducers of regulated CREB (TORCs) are crucial for cAMP-responsive gene activation.
- Calcium Channels Get ROCKed
ROCK mediates the regulation of T-type Ca2+ channels by lysophosphatidic acid.
- Decision-Making in the Fly
Drosophila require dopamine neurons within a memory-related area of the brain to make nuanced choices between similar stimuli.
- Yeast In Synch
Yeast cells in alternating respiratory and glycolytic phases synthesize new DNA and divide only during glycolysis, avoiding high mutation rates that characterize respiration.
- Timeless Changes
A recent variant of a circadian clock gene may alter diapause timing in wild European Drosophila, and selection may explain its north-south distribution.
- Decap to Form Veins
The mRNA decay pathway that involves decapping is essential to proper plant development.
- A New E1 Activation System for Ubiquitin
A newly characterized E1 ubiquitin-activating enzyme brings new complexity to the regulation of ubiquitination.
- Allosteric Activation of Toll-Like Receptor Activity
Toll-like receptor 9 undergoes conformational changes upon binding activating DNA ligands that are transmitted to the intracellular signaling domains.
