Contents
Vol 2007, Issue 394
Contents
Editorial Guide
- Focus Issue: STNG—Signal Transduction, the Next Generation
STKE supports teachers and students to foster science education.
Journal Club
- Ceramide: From Embryos to Tumors
A better understanding of the role of ceramides in apoptosis may lead to new antineoplastic therapies.
Teaching Resources
- A Biochemical Assay for Acetylcholinesterase Activity in PC12 Cells
Students use a spectrophotometric assay to assess neuronal differentiation.
- Instructing Graduate Students to Tackle the "Real World": A Course Description
This Teaching Resource describes a course intended to prepare students for a future in scientific research.
- Introduction to Enzyme Kinetics: Assay of β-Galactosidase
Use this online tutorial to teach the basics of enzyme kinetics.
Editors' Choice
- Signaling Endosomes Point the Way
Brain-derived neurotrophic factor (BDNF) promotes migration of granule cells by triggering the accumulation of endosomes at the leading edge that contain the neurotrophin receptor TrkB.
- Converting Attraction to Repulsion
Opposing actions of LIM kinase and the phosphatase Slingshot regulate growth cone turning, with calcium shifting the balance toward Slingshot.
- Numb Cells Keep Moving
The adaptor protein Numb is necessary for integrin endocytosis and polarized migration.
- Hedgehog Likes (to) Dally
The glypican Dally associates with Lipophorin to enhance Hedgehog signaling.
- Balanced on One Foot
Crystallography studies reveal the molecular details about glycolipid presentation by Cd1d to natural killer cell T cell receptors.
- Treating Parkinson's the CDNF Way
A new neurotrophin promotes survival of dopaminergic neurons in a model of Parkinson's disease.
- Inflammation and Tumor Progression
A cell signaling protein associated with the innate immune response is linked to a pathway that supports cancer progression.
- Possible Role for Deacetylation in DNA Damage Response
Deacetylation of a protein that functions in detection and repair of DNA damage appears to influence its regulation by phosphorylation.