Contents

Contents

• Editorial Guide

  • Focus Issue: STNG—Signal Transduction, the Next Generation

    By Elizabeth M. Adler, Nancy R. Gough

    Science's STKE10 Jul 2007 : eg6 Full AccessRestricted Access

    STKE supports teachers and students to foster science education.

    • Abstract
    • Full Text
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• Journal Club

  • Ceramide: From Embryos to Tumors

    By Iaroslav A. Savtchouk, Floyd J. Mattie, Anne A. Ollis

    Science's STKE10 Jul 2007 : jc1 Full AccessRestricted Access

    A better understanding of the role of ceramides in apoptosis may lead to new antineoplastic therapies.

    • Abstract
    • Full Text
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• Teaching Resources

  • A Biochemical Assay for Acetylcholinesterase Activity in PC12 Cells

    By Paul J. Schwartz, Jay A. Blundon, Elizabeth M. Adler

    Science's STKE10 Jul 2007 : tr2 Full AccessRestricted Access

    Students use a spectrophotometric assay to assess neuronal differentiation.

    • Abstract
    • Full Text
    • PDF

  • Instructing Graduate Students to Tackle the "Real World": A Course Description

    By Randen L. Patterson

    Science's STKE10 Jul 2007 : tr3 Full AccessRestricted Access

    This Teaching Resource describes a course intended to prepare students for a future in scientific research.

    • Abstract
    • Full Text
    • PDF

  • Introduction to Enzyme Kinetics: Assay of β-Galactosidase

    By Joanne Kivela Tillotson

    Science's STKE10 Jul 2007 : tr4 Full AccessRestricted Access

    Use this online tutorial to teach the basics of enzyme kinetics.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Signaling Endosomes Point the Way

    By Nancy R. Gough

    Science's STKE10 Jul 2007 : tw240 Full AccessRestricted Access

    Brain-derived neurotrophic factor (BDNF) promotes migration of granule cells by triggering the accumulation of endosomes at the leading edge that contain the neurotrophin receptor TrkB.

    • Abstract

  • Converting Attraction to Repulsion

    By Elizabeth M. Adler

    Science's STKE10 Jul 2007 : tw241 Full AccessRestricted Access

    Opposing actions of LIM kinase and the phosphatase Slingshot regulate growth cone turning, with calcium shifting the balance toward Slingshot.

    • Abstract

  • Numb Cells Keep Moving

    By John F. Foley

    Science's STKE10 Jul 2007 : tw242 Full AccessRestricted Access

    The adaptor protein Numb is necessary for integrin endocytosis and polarized migration.

    • Abstract

  • Hedgehog Likes (to) Dally

    By John F. Foley

    Science's STKE10 Jul 2007 : tw243 Full AccessRestricted Access

    The glypican Dally associates with Lipophorin to enhance Hedgehog signaling.

    • Abstract

  • Balanced on One Foot

    By Nancy R. Gough

    Science's STKE10 Jul 2007 : tw244 Full AccessRestricted Access

    Crystallography studies reveal the molecular details about glycolipid presentation by Cd1d to natural killer cell T cell receptors.

    • Abstract

  • Treating Parkinson's the CDNF Way

    By Nancy R. Gough

    Science's STKE10 Jul 2007 : tw245 Full AccessRestricted Access

    A new neurotrophin promotes survival of dopaminergic neurons in a model of Parkinson's disease.

    • Abstract

  • Inflammation and Tumor Progression

    By L. Bryan Ray

    Science's STKE10 Jul 2007 : tw246 Full AccessRestricted Access

    A cell signaling protein associated with the innate immune response is linked to a pathway that supports cancer progression.

    • Abstract

  • Possible Role for Deacetylation in DNA Damage Response

    By L. Bryan Ray

    Science's STKE10 Jul 2007 : tw247 Full AccessRestricted Access

    Deacetylation of a protein that functions in detection and repair of DNA damage appears to influence its regulation by phosphorylation.

    • Abstract