Contents
Vol 2007, Issue 395
Contents
Perspective
- Does Erythropoietin Have a Dark Side? Epo Signaling and Cancer Cells
Clinical studies have raised the possibility of a growth-promoting action of Epo on cancer cells.
Editors' Choice
- From Protein Interactions to Complex Physiology
Distinct subsets of the available interaction domains of a scaffolding protein are recruited in muscle and heart to support tissue-specific developmental programs.
- Hormones Are Not Enough
Cytokines better known for controlling T cell differentiation are now implicated in mammary epithelial cell differentiation.
- Balancing Act
The decision to promote distinct immune cells, which either prevent or promote inflammation, is regulated by the vitamin A metabolite retinoic acid.
- Redox Receptor Regulation Revealed
Excreted thioredoxin appears to modulate receptor signaling.
- A Shocking Use for CD6?
CD6 binds pathogen-associated molecular patterns present on bacteria and may prove useful in the therapy of septic shock.
- Internal P2X Receptors
An ATP receptor on the contractile vacuole is needed for osmoregulation in Dictyostelium discoideum.
- A New Partner for c-Myc
CIP2A promotes cellular transformation by blocking PP2A-mediated dephosphorylation of c-Myc.
- Crystallized Kinase Regulation
Structural and functional studies suggest that mutations in two noncatalytic domains of an important kinase can cause cancer by releasing an inhibitor.
- Growth Hormone and Development
A repetitive DNA segment in the growth hormone gene is transcribed during pituitary development and establishes chromatin structure for activation of gene transcription.
- Cohesin Does the Business
The close association of two sister chromatids can occur as a result of DNA damage and does not require simultaneous DNA replication, as previously thought.
