17 July 2007
Vol 2007, Issue 395
  • Contents

    • Perspective

    • Editors' Choice

      • From Protein Interactions to Complex Physiology

        Distinct subsets of the available interaction domains of a scaffolding protein are recruited in muscle and heart to support tissue-specific developmental programs.

      • Hormones Are Not Enough

        Cytokines better known for controlling T cell differentiation are now implicated in mammary epithelial cell differentiation.

      • Balancing Act

        The decision to promote distinct immune cells, which either prevent or promote inflammation, is regulated by the vitamin A metabolite retinoic acid.

      • A Shocking Use for CD6?

        CD6 binds pathogen-associated molecular patterns present on bacteria and may prove useful in the therapy of septic shock.

      • Internal P2X Receptors

        An ATP receptor on the contractile vacuole is needed for osmoregulation in Dictyostelium discoideum.

      • A New Partner for c-Myc

        CIP2A promotes cellular transformation by blocking PP2A-mediated dephosphorylation of c-Myc.

      • Crystallized Kinase Regulation

        Structural and functional studies suggest that mutations in two noncatalytic domains of an important kinase can cause cancer by releasing an inhibitor.

      • Growth Hormone and Development

        A repetitive DNA segment in the growth hormone gene is transcribed during pituitary development and establishes chromatin structure for activation of gene transcription.

      • Cohesin Does the Business

        The close association of two sister chromatids can occur as a result of DNA damage and does not require simultaneous DNA replication, as previously thought.

About The Cover

Cover image expansion

COVER This week features a Perspective on erythropoietin (Epo) signaling and the possibility that Epo may promote the growth of cancer cells. The image depicts two possible forms of the Epo receptor (a homodimer and a heterodimer) that may mediate Epo signaling in cancer cells. [Image: Preston Huey, AAAS]