Contents
Vol 2007, Issue 396
Contents
Perspectives
- Keeping the (Kinase) Party Going: SLP-76 and ITK Dance to the Beat
The adaptor protein SLP-76 serves as more than a neutral adaptor during T cell activation.
- Chemotaxis: Navigating by Multiple Signaling Pathways
Multiple signaling pathways promote cell movement through a chemoattractive gradient.
Editors' Choice
- Oncogenic Ras-Induced Interleukin-6 Promotes Tumor Growth
Tumor growth of oncogenic Ras-expressing cells is dependent on interleukin-6.
- Dispersing Clusters with Calpain
The activity of calpain appears to control whether acetylcholine receptors cluster or disperse.
- Hearing New Things About Calcium
Otopetrin 1, a multitransmembrane protein critical to otoconia formation, modulates the Ca2+ response to ATP.
- Location, Location, Location
Signaling on cilia occurs when a soluble ligand binds to a receptor and relieves an inhibitory interaction, allowing regulation of development and other processes.
- Everyone Gets to Drive
During Drosophila border cell migration, exchange of the leading cell allows collective guidance of the cluster.
- Longevity on the Brain
Mice engineered with a brain-specific decrease in insulin-like signaling have their life spans extended as much as those in mice with a similar defect throughout their bodies.
- To Cluster or Not to Cluster
The variations in binding selectivity of a common protein binding domain are evenly distributed in selectivity space, rather than arranged in discrete clusters as had been assumed.
- Minimal Exposure
Cytomegalovirus aids its own survival by encoding a microRNA that inhibits, in the infected host cell, translation of a ligand that would normally trigger antiviral responses.
- What’s the Buzz
Honey bee hives with genetically diverse members stored more food and thus survived better than those with members from a single male founder.
