24 July 2007
Vol 2007, Issue 396
  • Contents

    • Perspectives

    • Editors' Choice

      • Dispersing Clusters with Calpain

        The activity of calpain appears to control whether acetylcholine receptors cluster or disperse.

      • Hearing New Things About Calcium

        Otopetrin 1, a multitransmembrane protein critical to otoconia formation, modulates the Ca2+ response to ATP.

      • Location, Location, Location

        Signaling on cilia occurs when a soluble ligand binds to a receptor and relieves an inhibitory interaction, allowing regulation of development and other processes.

      • Everyone Gets to Drive

        During Drosophila border cell migration, exchange of the leading cell allows collective guidance of the cluster.

      • Longevity on the Brain

        Mice engineered with a brain-specific decrease in insulin-like signaling have their life spans extended as much as those in mice with a similar defect throughout their bodies.

      • To Cluster or Not to Cluster

        The variations in binding selectivity of a common protein binding domain are evenly distributed in selectivity space, rather than arranged in discrete clusters as had been assumed.

      • Minimal Exposure

        Cytomegalovirus aids its own survival by encoding a microRNA that inhibits, in the infected host cell, translation of a ligand that would normally trigger antiviral responses.

      • What’s the Buzz

        Honey bee hives with genetically diverse members stored more food and thus survived better than those with members from a single male founder.

About The Cover

Cover image expansion

COVER This week features a Perspective on Dictyostelium chemotaxis. The image shows the various ways that movement can be controlled during Dictyostelium migration. [Image: Christopher Bickel, AAAS]