Editors' ChoicePhysiology

Longevity on the Brain

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Science's STKE  24 Jul 2007:
Vol. 2007, Issue 396, pp. tw264
DOI: 10.1126/stke.3962007tw264

Several studies show that loss-of-function mutations in the insulin-like signaling cascade extend the life span of worms and flies; however, equivalent mutations are associated with metabolic disease and fatal diabetes in mice. In contrast, calorie restriction or genetic strategies in mice that enhance insulin sensitivity lower the risk of age-related disease and extend life span. Taguchi et al. resolve these conflicting results by pointing to the brain as the site where reduced insulin-like signaling can extend mouse life span.

A. Taguchi, L. M. Wartschow, M. F. White, Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372 (2007). [Abstract] [Full Text]

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