Contents
Vol 2007, Issue 397
Contents
Perspective
- Molecular Scaffolds Regulate Bidirectional Crosstalk Between Wnt and Classical Seven-Transmembrane Domain Receptor Signaling Pathways
Downstream components interact to allow crosstalk between classical and atypical seven-transmembrane domain receptors.
Editors' Choice
- An Arrestin Immune Response
β-Arrestin-1 plays a key role in CD4+ T cell homeostasis by regulating the expression of Bcl-2.
- BAK1 for Pathogen Response
The leucine-rich repeat receptor-like kinase BAK1 interacts with pathogen-associated molecular pattern receptors to allow plants to respond to pathogens.
- Sensing Cytosolic DNA
DAI is a protein that triggers interferon gene expression and the innate immune response when cells are exposed to cytosolic DNA.
- Twisted Signaling
Crystal structures reveal how stem cell factor drives Kit receptor dimerization.
- Essence of Alpha Male
Neurogenesis in the olfactory bulb and hippocampus of female mice is stimulated by the odors of the alpha male, which helps the female select the best mate.
- Sensor Evolution in Action
Strains of photosynthetic bacteria use a nearly identical protein to sense light or oxygen concentrations.
- Ethylene Controls Root Meristem Production
Stem cell proliferation in a niche within developing roots is limited by the gaseous hormone ethylene.
- Leukotriene Synthesis Inhibitors in a FLAP
The structure of a human membrane protein involved in biosynthesis of the inflammation-related leukotrienes may help guide the development of therapeutics.
- Noise, Gene Expression, and Competence
Bacteria that show more random fluctuations in gene expression are especially likely to switch to an alternative phenotype in which they can take up foreign genetic material.
- Correcting Cocaine-Induced Plasticity
A decrease in the effectiveness of synapses in a particular brain region is caused by replacement of one glutamate receptor subtype with a less efficient one.
