07 August 2007
Vol 2007, Issue 398
  • Contents

    • Editorial Guide

    • Perspectives

    • Review

    • Editors' Choice

      • Toxic Mother's Milk

        Milk from mothers deficient in PPARγ, a transcription factor that regulates lipid biosynthesis, is high in inflammatory lipids and toxic to nursing pups.

      • Switching on the Ras Signal

        Membrane microdomains that act as "nanoswitches" may be crucial for high-fidelity signal transduction.

      • Sleepy Time with TNF-α

        TNF-α suppresses the expression of clock genes, leading to the fatigue associated with microbial infections.

      • Matchmaking in Plants

        In plants, a female-specific kinase senses the arrival of the pollen tube, setting the stage for the next stages of fertilization and potentially controlling reproductive compatibility.

      • Slit Has Complex Effects

        Slit not only coordinates axonal guidance and adhesion but also stimulates formation of a complex that releases β-catenin from N-cadherin, enabling changes in gene transcription.

      • Scratch and See

        Wnt signaling and Cdc42 cooperate to reorient the cell’s organelles.

      • Insulin Signaling Up Close and Personal

        Identifying the genetic and protein targets of the insulin signaling pathway in C. elegans reveals mechanisms that potentially control the aging process.

      • Leukocytes on Border Patrol

        Immune cells that reside in endothelial tissues remain attached to the walls of blood vessels and survey for signs of damage and infection.

      • Keeping Tabs on a TLR Response

        In mice, the innate immune response to microbes is controlled by blocking degradation of a transcriptional inhibitor, dampening an otherwise potentially dangerous response.

      • Monitoring Cellular Mechanical Stress

        Fluorescent labeling of cysteines in living cells reveals how mechanical stress can cause force-induced conformational changes in cellular proteins.

About The Cover

Cover image expansion

COVER This week's Focus Issue, published to complement the Science Special Issue on Challenges in Immunology, contains an Editorial Guide, a Review, and two Perspectives that discuss signals that affect the fate and responsiveness of T lymphocytes. The image depicts the activation of a naïve CD4+ T lymphocyte by a dendritic cell and its subsequent expansion and differentiation into a long-lived memory cell. [Image: Preston Huey, AAAS]