Toll-Like Receptors in Brain Development and Homeostasis

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Science's STKE  04 Sep 2007:
Vol. 2007, Issue 402, pp. pe47
DOI: 10.1126/stke.4022007pe47

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  • Understanding the Role of TLRs in Nervous System Repair

    The experiments reported by Boivin and colleagues complement those discussed in the Perspective, and make a significant contribution to our understanding of the role of TLRs in nervous system repair. Notable advances are the fact that the lesion was a peripheral (sciatic) nerve lesion, in some ways similar to a facial nerve lesion, but inducing locomotor function disability, recovery from which could then be measured. Waller...

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    Competing Interests: None declared.
  • TLRs in the Peripheral Nervous System, Too

    As Larsen et al. highlight in their Perspective, Toll-like receptors (TLRs) appear to have important roles in development of the central nervous system (CNS) and response to CNS injury. As Boivin et al. report in the Journal of Neuroscience, TLR signaling appears important for recovery from injury in the peripheral nervous system, too. Their experiments with mice deficient in TLR signaling show that recovery from...

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    Competing Interests: None declared.

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