11 September 2007
Vol 2007, Issue 403
  • Contents

    • Perspectives

    • Editors' Choice

      • Sequestered at the Golgi

        RKTG appears to trap Raf-1 at the Golgi and inhibit activation of the mitogen-activated protein kinase cascade.

      • A Faster Route Up?

        5-HT4 receptor agonists hold promise for the possibility of a more rapidly acting class of antidepressants.

      • The Molecular Machinery of Mood Swings

        The structure of an antidepressant drug bound to a bacterial transporter reveals how these drugs may work on neurotransmitter transporters in humans.

      • MyD88-5 and Neuronal Toxicity

        The adaptor protein MyD88-5 mediates stress-induced death of neurons.

      • Hydrogen Peroxide and Blood Pressure

        An unusual redox-triggered dimerization can, like nitric oxide, activate cyclic GMP-dependent kinase to reduce blood pressure by decreasing tension in blood vessel walls.

      • Reciprocal Regulation of DAPK

        The tyrosine phosphatase LAR and the tyrosine kinase Src regulate the tumor suppressor DAPK.

      • Polo Playing with Numb

        Polo provides a link between the cell cycle and the asymmetric localization of Numb.

      • Helping Plants Survive Heat Stress

        Fungi associated with the roots of plants release chemicals that inhibit heat shock protein 90 and allow enhanced thermotolerance.

About The Cover

Cover image expansion

COVER This week features a Perspective on hedgehog signaling. The image shows cells close to and more distant from a source of the morphogen Sonic hedgehog. [Image: Christopher Bickel, AAAS]