Contents
Vol 2007, Issue 404
Contents
Perspectives
- Dialogue Between LKB1 and AMPK: A Hot Topic at the Cellular Pole
LKB1 appears to be a novel class of tumor suppressor that acts as an energy-sensing and polarity checkpoint.
- β-Actin: A Regulator of NOS-3
β-actin regulates the activity of NOS-3 directly and indirectly through Hsp90.
Editors' Choice
- Endogenous Enhancers of Toll-Like Receptor 4
Myeloid-related proteins 8 and 14 enhance responses of Toll-like receptor 4 to lipopolysaccharide and promote death.
- Tailor-Made Toll-Like Receptor
An innate immune receptor in humans selectively protects against severe infection of the central nervous system by herpes simplex virus 1.
- Regulating Glucose
Glucose sensing by hypothalamic proopiomelanocortin neurons is implicated in systemic glucose homeostasis and lost in obese mice fed a high-fat diet.
- Establishing Asymmetry
The microRNAs miR-15 and miR-16 link asymmetry in Wnt/β-catenin to asymmetry in Nodal signaling and thereby play a crucial role in regulating embryonic patterning.
- Preventing Transformation
Organized epithelial structures resist transformation through a mechanism involving LKB1.
- Functional Evolution of Proteins
The structure of a 450-million-year-old corticoid receptor, resurrected computationally and biochemically, suggests how modern hormone receptors evolved.