Contents

Contents

• Perspectives

  • Dialogue Between LKB1 and AMPK: A Hot Topic at the Cellular Pole

    By Christelle Forcet, Marc Billaud

    Science's STKE18 Sep 2007 : pe51 Full AccessRestricted Access

    LKB1 appears to be a novel class of tumor suppressor that acts as an energy-sensing and polarity checkpoint.

    • Abstract
    • Full Text
    • PDF

  • β-Actin: A Regulator of NOS-3

    By Yunchao Su, Dmitry Kondrikov, Edward R. Block

    Science's STKE18 Sep 2007 : pe52 Full AccessRestricted Access

    β-actin regulates the activity of NOS-3 directly and indirectly through Hsp90.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Endogenous Enhancers of Toll-Like Receptor 4

    By John F. Foley

    Science's STKE18 Sep 2007 : tw334 Full AccessRestricted Access

    Myeloid-related proteins 8 and 14 enhance responses of Toll-like receptor 4 to lipopolysaccharide and promote death.

    • Abstract

  • Tailor-Made Toll-Like Receptor

    By Stephen J. Simpson

    Science's STKE18 Sep 2007 : tw335 Full AccessRestricted Access

    An innate immune receptor in humans selectively protects against severe infection of the central nervous system by herpes simplex virus 1.

    • Abstract

  • Receptor Swapping

    By L. Bryan Ray

    Science's STKE18 Sep 2007 : tw336 Full AccessRestricted Access

    Neutrophils put receptors borrowed from platelets to good use.

    • Abstract

  • Regulating Glucose

    By Elizabeth M. Adler

    Science's STKE18 Sep 2007 : tw337 Full AccessRestricted Access

    Glucose sensing by hypothalamic proopiomelanocortin neurons is implicated in systemic glucose homeostasis and lost in obese mice fed a high-fat diet.

    • Abstract

  • Establishing Asymmetry

    By Elizabeth M. Adler

    Science's STKE18 Sep 2007 : tw338 Full AccessRestricted Access

    The microRNAs miR-15 and miR-16 link asymmetry in Wnt/β-catenin to asymmetry in Nodal signaling and thereby play a crucial role in regulating embryonic patterning.

    • Abstract

  • Preventing Transformation

    By Nancy R. Gough

    Science's STKE18 Sep 2007 : tw339 Full AccessRestricted Access

    Organized epithelial structures resist transformation through a mechanism involving LKB1.

    • Abstract

  • Functional Evolution of Proteins

    By Valda J. Vinson

    Science's STKE18 Sep 2007 : tw340 Full AccessRestricted Access

    The structure of a 450-million-year-old corticoid receptor, resurrected computationally and biochemically, suggests how modern hormone receptors evolved.

    • Abstract