Contents
Vol 2007, Issue 407
Contents
Editorial Guide
- Cell Signaling: Details, Details, Details
New pathways and updates to the Database of Cell Signaling highlight how cells respond to stimuli and changing environmental conditions.
Editors' Choice
- A Long, Deprived Life or a Short, Sweet One?
Glucose restriction may increase life span through an AMPK-dependent increase in ROS production.
- How Clocks See the Light
Hydrogen peroxide functions in entrainment of the zebrafish circadian clock in response to light.
- Harming Thyself
An antimicrobial peptide, LL37, complexes with self-DNA to trigger interferon-α production by plasmacytoid dendritic cells.
- Released from the Nucleolus
Phosphorylation of the transcription factor Hand1 releases it from the nucleolus, allowing cell differentiation.
- Keeping p53 in the Nucleus
Poly(ADP-ribosyl)ation of p53 in response to DNA damage prevents its interaction with the nuclear export receptor.
- Too Close for Molecular Comfort
The STIM1-Orai1 complex likely involves additional components.
- Learning, Autism, and the Synapse
A mouse model reveals that a mutation that changes the balance of excitatory and inhibitory synapses affects learning skills, a finding that may help in understanding autism.
- Neuronal Road Map
Glial cells can orchestrate neuron-to-neuron connections by attracting processes from the postsynaptic cell and triggering synapse formation in the presynaptic cell.
- Plant Protector Identified
In response to viral infection, tobacco plants locally produce methyl salicylate, which then spreads and renders the whole plant more resistant to subsequent infections.
- The Silence of the Flowering Genes
Two proteins known to participate in flowering are also required for chromatin silencing at various genetic loci early in Arabidopsis development.
Connections Map Overviews
- PI3K Class IB Pathway
Class IB PI3K is involved in coordinating the body's response to injury and infection.
- PI3K Class IB Pathway in Neutrophils
This lipid signaling pathway regulates adhesion, chemotaxis, secretion, and the "respiratory burst" in neutrophils.
- Cytokinin Signaling Pathway
Cytokinin signaling involves a multistep phosphorelay system.
- Arabidopsis Cytokinin Signaling Pathway
Cytokinin effects in Arabidopsis depend on cell type, environment, and developmental stage, with the response often involving interactions with other signaling pathways.
- Hedgehog Signaling Pathway
The primary cilium is involved in mammalian Hedgehog signaling.
- Hedgehog Signaling Pathway in Drosophila
Fruitflies have served as a key model system for understanding the mechanisms that underlie the response to Hedgehog.
- Hypoxia-Inducible Factor 1 (HIF-1) Pathway
HIF-1 mediates signaling allows cells to survive O2 deprivation.
