16 October 2007
Vol 2007, Issue 408
  • Contents

    • Perspectives

    • Editors' Choice

      • An Active Player

        The scaffolding protein INAD plays a dynamic role in Drosophila phototransduction.

      • Phosphorylated Cofilin Not Inactive After All

        Although phosphorylated cofilin is inactive for its role as an actin-depolymerizing factor, it does have a role in mediating G protein-coupled receptor stimulation of phospholipase D.

      • Fight, Flight, or Inflame

        Adrenaline and noradrenaline released from phagocytes make inflammation worse.

      • Endothelial Cells as Salt Sensors

        Endothelial cells that line the blood vessels appear to stiffen in response to small changes in sodium concentration.

      • An Endogenous SERM?

        The cholesterol metabolite 27-hydroxycholesterol may act as an endogenous SERM.

      • Unraveling PKA Isoform Specificity

        The structure of the catalytic subunit of cyclic AMP-dependent protein kinase bound to a regulatory subunit reveals how this enzyme activates two different signaling pathways.

      • Slowing Tumor Growth with a One-Two Punch

        In glioblastoma cancer cells, drugs that work by inhibiting receptor tyrosine kinases are more powerful in combination than when administered alone.

      • MicroRNAs Strike a Balance

        A novel technology to disrupt miRNA-mRNA interactions reveals that some miRNAs may repress antagonistic developmental regulators.

      • Almost in a Day’s Work

        Flowering is triggered only when both light and enough of a particular protein are available in the afternoon, conditions only satisfied during longer days of spring.

      • Signaling Between Symbiotic Partners

        Lysophospholipids made in the roots of tomato and potato plants, which grow in association with mycorrhizal fungi, induce genes for phosphate transfer in the fungi.