16 October 2007
Vol 2007, Issue 408
  • Contents

    • Perspectives

    • Editors' Choice

      • An Active Player

        The scaffolding protein INAD plays a dynamic role in Drosophila phototransduction.

      • Phosphorylated Cofilin Not Inactive After All

        Although phosphorylated cofilin is inactive for its role as an actin-depolymerizing factor, it does have a role in mediating G protein-coupled receptor stimulation of phospholipase D.

      • Fight, Flight, or Inflame

        Adrenaline and noradrenaline released from phagocytes make inflammation worse.

      • Endothelial Cells as Salt Sensors

        Endothelial cells that line the blood vessels appear to stiffen in response to small changes in sodium concentration.

      • An Endogenous SERM?

        The cholesterol metabolite 27-hydroxycholesterol may act as an endogenous SERM.

      • Unraveling PKA Isoform Specificity

        The structure of the catalytic subunit of cyclic AMP-dependent protein kinase bound to a regulatory subunit reveals how this enzyme activates two different signaling pathways.

      • Slowing Tumor Growth with a One-Two Punch

        In glioblastoma cancer cells, drugs that work by inhibiting receptor tyrosine kinases are more powerful in combination than when administered alone.

      • MicroRNAs Strike a Balance

        A novel technology to disrupt miRNA-mRNA interactions reveals that some miRNAs may repress antagonistic developmental regulators.

      • Almost in a Day’s Work

        Flowering is triggered only when both light and enough of a particular protein are available in the afternoon, conditions only satisfied during longer days of spring.

      • Signaling Between Symbiotic Partners

        Lysophospholipids made in the roots of tomato and potato plants, which grow in association with mycorrhizal fungi, induce genes for phosphate transfer in the fungi.

About The Cover

Cover image expansion

COVER This week features a Perspective on glutamate receptor clustering. The image depicts some of the proteins involved in AMPA receptor clustering. [Image: Christopher Bickel, AAAS]