23 October 2007
Vol 2007, Issue 409
  • Contents

    • Review

    • Editors' Choice

      • VHL: Ligase and Kinase Adaptor

        By promoting the interaction between the kinase CK2 and CARD9, VHL inhibits NF-κB signaling.

      • Unraveling Ras Interactions

        A model of cell signaling reveals why only one mutated form of an oncogene occurs in tumors and suggests a strategy for selective inhibition of oncogene-containing cells.

      • Lock and Load

        Helicobacter pylori engages and activates integrins on gastric epithelial cells before injecting virulence factors.

      • The Best Offense Is Someone Else’s Defense

        A bacterial plant pathogen co-opts one of the plant’s own defense proteins to facilitate transfer of its infectious DNA into the nucleus.

      • Interferon’s New Weapon

        Interferon increases the abundance of microRNAs that inhibit replication of the hepatitis C virus.

      • Roundabout the Dendritic Tree?

        Slit signaling through Robo regulates dendrogenesis in the central nervous system.

      • Clocks in the Corals

        Primitive photoreceptors in a reef-building coral respond to subtle changes in light, suggesting that they help trigger the mass spawning of corals on the Great Barrier Reef.

      • Off with the Methyl Marks

        An enzyme is discovered that removes methyl groups from arginines in histone proteins, which together with DNA form the bulk of chromatin and help regulate gene expression.

About The Cover

Cover image expansion

COVER This week features a Review concerning the possible role of asparagine deamidation as a genetically programmed molecular timer of biological processes. [Image: Christopher Bickel, AAAS]