30 October 2007
Vol 2007, Issue 410
  • Contents

    • Editorial Guide

    • Perspectives

    • Editors' Choice

      • Ras Versus Fas

        Oncogenic Ras directs the epigenetic silencing of genes that inhibit tumorigenesis.

      • A "Rsk"y Shortcut in Dendritic Cells

        In dendritic cells, the "cis" function of one of the two kinase domains of Rsk protein kinases can be replaced "in trans" by another MAPK-activated protein kinase.

      • ADP for ATP Exchange Mechanism

        The NOD protein MalT appears to cycle between an ADP-bound inactive state and an ATP-bound active state.

      • Need ADP to See

        Adenosine diphosphate signaling initiates development of the eye.

      • Providing a Calcium Source

        Localization of BK channels to lipid rafts may enable IP3-mediated signaling pathways to activate BK channels in glioma cells.

      • Extracellular Death Factor

        A small peptide mediates programmed cell death in a bacterial population, offsetting starvation, clearing a toxin, or halting the spread of a virus infection.

      • Plant-Pathogen Arms Race

        In pepper plants, a protein from a bacterial pathogen acts as a transcription factor that both elongates cells, the characteristic sign of infection, and induces a defensive response.

      • The Makings of Self-Pollination

        Unlike their ancestors, domesticated tomatoes self-fertilize because a cell elongation mutation causes short styles, burying the female reproductive parts among male anthers.

About The Cover

Cover image expansion

COVER This week's Focus Issue, published in conjunction with the Science Special Collection on Decision-Making, highlights cellular decision-making events (see the Editorial Guide). The image depicts a neuronal stem cell and its potential fates of a glia or a neuron. [Image: Christopher Bickel, AAAS]