Contents
Vol 2007, Issue 411
Contents
Perspective
- Neurotrophic Factors and Parkinson’s Disease: The Emergence of a New Player?
Identification of a new family of neurotrophic factors raises hopes for new therapeutic strategies against Parkinson's disease.
Meeting Report
- Meeting Report: Zinc Signals 2007—Expanding Roles of the Free Zinc Ion in Biology
Zinc researchers are galvanized by new findings and technical advances in the field of ionic zinc signaling.
Editors' Choice
- A New Angiogenesis Inhibitor
Antibodies directed against PIGF may be useful in cancer therapy.
- Inhibiting Akt
Full-length and caspase-cleaved forms of the serine-threonine kinase Mst1 inhibit Akt activity.
- Modulating Intraorganelle Communication
Sig-1Rs act as ligand- and calcium-modulated ER chaperones that modulate ER-mitochondrial signaling.
- Shifting Receptor Sensitivities
A quinoxalinedione glutamate receptor antagonist becomes an agonist when the receptor acquires an extra subunit, coupling changes in ligand binding to opening of the channel.
- Commonalities Between pDCs and B Cells
Plasmacytoid dendritic cells signal through a cascade very similar to that activated by B cell receptors.
- Of Life and Limb
Forelimb regeneration in newts requires concomitant regeneration of the nerve, a necessity that can be circumvented by application of a single protein, nAG.
- Molecular Culprit in Gestational Diabetes
A study of mice identifies a protein that may malfunction in gestational diabetes, a common complication of pregnancy.
- Dissecting a Core Oscillator
The cycling of three protein components comprising the circadian clock in cyanobacteria is driven by a pattern of sequential phosphorylation that can be described mathematically.
- Dynamic Developmental Gene Regulation
The ring of gene expression that sweeps across sea urchin embryos is controlled by a regulatory circuit that generates a wave of activation followed by a wave of repression.
