06 November 2007
Vol 2007, Issue 411
  • Contents

    • Perspective

    • Meeting Report

    • Editors' Choice

      • A New Angiogenesis Inhibitor

        Antibodies directed against PIGF may be useful in cancer therapy.

      • Inhibiting Akt

        Full-length and caspase-cleaved forms of the serine-threonine kinase Mst1 inhibit Akt activity.

      • Shifting Receptor Sensitivities

        A quinoxalinedione glutamate receptor antagonist becomes an agonist when the receptor acquires an extra subunit, coupling changes in ligand binding to opening of the channel.

      • The Sound of Silence

        ATP stimulates action potentials in developing auditory neurons.

      • Commonalities Between pDCs and B Cells

        Plasmacytoid dendritic cells signal through a cascade very similar to that activated by B cell receptors.

      • Of Life and Limb

        Forelimb regeneration in newts requires concomitant regeneration of the nerve, a necessity that can be circumvented by application of a single protein, nAG.

      • Molecular Culprit in Gestational Diabetes

        A study of mice identifies a protein that may malfunction in gestational diabetes, a common complication of pregnancy.

      • Dissecting a Core Oscillator

        The cycling of three protein components comprising the circadian clock in cyanobacteria is driven by a pattern of sequential phosphorylation that can be described mathematically.

      • Dynamic Developmental Gene Regulation

        The ring of gene expression that sweeps across sea urchin embryos is controlled by a regulatory circuit that generates a wave of activation followed by a wave of repression.

About The Cover

Cover image expansion

COVER This week features a Perspective on neurotrophic factors as a possible approach to the therapy of Parkinson's disease and other neurodegenerative disorders. The image depicts a brain. [Image: Christopher Bickel, AAAS]