Editors' ChoicePhysiology

Molecular Culprit in Gestational Diabetes

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Science's STKE  06 Nov 2007:
Vol. 2007, Issue 411, pp. tw406
DOI: 10.1126/stke.4112007tw406

During pregnancy, maternal pancreatic islet β-cells expand to accommodate the increasing physiological demands placed on the mother by the growing fetus. The molecular mechanisms controlling this physiological response, which helps prevent the development of "gestational diabetes" in the mother, have been unclear. Studying mouse models, Karnik et al. now show that menin, a protein previously identified as an endocrine tumor suppressor and transcriptional regulator, inhibits the growth of islet β-cells during pregnancy. Transgenic expression of menin in maternal β-cells prevented islet expansion and caused the mice to develop several hallmark features of gestational diabetes. Menin appears to be maintained at low levels in islets through the actions of the pregnancy-associated hormone prolactin.

S. K. Karnik, H. Chen, G. W. McLean, J. J. Heit, X. Gu, A. Y. Zhang, M. Fontaine, M. H. Yen, S. K. Kim, Menin controls growth of pancreatic β-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318, 806-809 (2007). [Abstract] [Full Text]

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