13 November 2007
Vol 2007, Issue 412
  • Contents

    • Perspectives

    • Review

    • Editors' Choice

      • Shifting from Spreading to Retraction

        Calpain cleavage of the integrin β3 cytoplasmic domain switches the integrin signal to promote cell retraction instead of cell spreading.

      • Arcadlin Signals Internalization

        By triggering coendocytosis of N-cadherin through a p38 MAPK pathway, arcadlin decreases the number of dendritic spines.

      • Life and Death Decisions

        When misfolded proteins accumulate within the endoplasmic reticulum, protective responses are initiated, but prolonged stress ultimately triggers cell death pathways.

      • STAT5A as a Tumor Suppressor

        Double-negative feedback regulates the oncogenic tyrosine kinase NPM-ALK and STAT5A.

      • Flow-Induced Asymmetry

        A morphological change limits blood flow to the right side branchial arch artery, leading to its regression.

      • Good Vibrations?

        Daily exposure to high-frequency, low-magnitude mechanical signals may attenuate adipocyte production.

      • LPS and Liver Fibrosis

        TLR4 signaling sensitizes hepatic stellate cells to TGF-β, thus enhancing fibrogenesis.

      • Turning Smo On

        Phosphorylation of the Smoothened protein alleviates an intramolecular inhibitory interaction of the cytoplasmic domain, allowing intermolecular interactions to occur.

      • Regulating the Regulators

        Nutrients turn on a regulator of cell growth and proliferation by displacing an inhibitor of the regulator’s kinase activity with a small guanosine triphosphatase.

      • Doing Double Duty

        The bacterium that causes Legionnaires’ disease recruits a host protein that regulates vesicle trafficking by mimicking host-activating proteins.

About The Cover

Cover image expansion

COVER This week features a Review on the mechanisms by which the PAR1 and SIP1 receptors regulate endothelial adherens junction integrity. The image depicts an adherens junction. [Image: Preston Huey, AAAS]