Contents
Vol 2007, Issue 415
Contents
Editorial Guide
- Focus Issue: Mastering Nuclear Dynamics
The nucleus is connected to cytoplasmic signaling networks and has its own complex signaling environment.
Perspectives
- Genomic Maintenance: The p53 Poly(ADP-ribosyl)ation Connection
In response to DNA damage, p53 is modified by poly(ADP-ribose) polymerase-1 (PARP-1) and accumulates in the nucleus.
- Nuclear Localization of Growth Hormone Receptor: Another Age of Discovery for Cytokine Action?
Translocation of the growth hormone receptor to the nucleus is linked with tumorigenesis.
Editors' Choice
- Two’s Company, Three’s a Complex
Ribosomal protein S3 is an essential subunit of NF-κB complexes that confers selectivity toward target genes.
- Looking After Polysialic Acid
The maturation of GABAergic inhibition--and thereby the onset of ocular dominance plasticity--is regulated by an activity-dependent decrease in polysialic acid.
- Losing RGS2 and a Taste for GHB
RGS2 decreases coupling between GABAB receptors and GIRK channels, thereby influencing the bidirectional effects of GABAB agonists on activity of ventral tegmental dopamine neurons.
- Delivering AMPA Receptors to the Synapse
cGMP-dependent protein kinase phosphorylates GluR1-type glutamate receptor subunits and increases their abundance at the cell surface.
- Antibiotics Target Akt
Targeting host kinases, such as Akt1, may be an effective strategy to control bacterial infection.
- Sensing the End
A pathogen-sensing protein of the innate immune system recognizes the 5′-triphosphate structures of single-stranded RNA present in many bacteria and viruses.
- Die Another Way
The invasion of one epithelial cell by another provides a nonapoptotic mechanism of cell death, entosis, which is dependent on adherens junction formation.
- Tacking Myelin Seams
A protein that forms particularly tight junctions between intestinal or endothelial cells also seals the ends of the myelin wrapping around nerve axons.
