11 December 2007
Vol 2007, Issue 416
  • Contents

    • Perspectives

    • Editors' Choice

      • Follow the Leader

        Squamous carcinoma cells follow tracks laid down by cancer-associated fibroblasts that invade and remodel a matrix.

      • Place Spindle Here

        Proper orientation of the spindle parallel to the substratum in cultured adherent nonpolarized cells requires phosphatidylinositol 3,4,5-trisphosphate.

      • Protecting the Liver from Death

        IGFBP1 binds BAK at the mitochondria, blocking p53 from triggering BAK oligomerization and inducing apoptosis.

      • Pain in the Brain

        A mechanism is revealed for the effects of noradrenaline on pain sensation in the brain.

      • Learn from Your Mistakes

        A gene variant that leads to fewer dopamine receptors also prevents people from learning from their mistakes and inhibits feedback to a brain area that registers bad outcomes.

      • Drugs, Psychosis, and Schizophrenia

        A psychosis-inducing drug activates a brain inflammatory enzyme system that produces superoxide, which decreases activity in certain GABA-containing interneurons.

      • Identification of a Deubiquitinating Enzyme

        Interferon secretion in response to viral infection is reduced by an enzyme that removes ubiquitin chains from proteins, an effect that could inhibit autoimmune disease.

      • Making the Right Cut

        Open and closed structures of an intramembrane protease reveal that it has six segments spanning the membrane and that its zinc active site is accessible only when it is open.

      • Avoiding Resistance

        Bt toxin, a natural insecticide engineered into plants, can be modified to overcome insect resistance by forming damaging pores in pests independently of its normal receptor.

About The Cover

Cover image expansion

COVER This week features a Perspective about signals that specify axons and dendrites. The image shows that active Rit (a GTPase) is more abundant in the axon, where it contributes to the growth of this neuronal process. [Image: Christopher Bickel, AAAS]