18 December 2007
Vol 2007, Issue 417
  • Contents

    • Perspective

    • Protocols

    • Editors' Choice

      • IP6 Got Rhythm?

        The inositol kinase Ipk1, which synthesizes IP6, regulates both the length and motion of cilia.

      • Bringing It All Together

        Lipid binding by the Par-3 PDZ2 domain is critical to its role in epithelial polarization.

      • PIKing Oncogenic Mutations

        Mutations commonly associated with cancer result in disrupted interactions between the domains of a growth-related lipid kinase and alter its regulation or activity.

      • TAMping Down Innate Immune Responses

        TAM receptor tyrosine kinases serve in a negative feedback loop to terminate Toll-like receptor signaling in dendritic cells.

      • The Pros and Cons of Acetylation

        The histone acetylase CLOCK contributes to both positive and negative feedback loops in regulation of circadian gene transcription.

      • Circadian Rhythm Methods

        Plants and animals adjust responses to their environments through small molecules, including metabolites, that interact with their circadian clocks.

      • Loss of Bactericidal Activity Promotes Infection

        Excess elastase in lungs of patients with cystic fibrosis or obstructive lung disease appears to cause cleavage of neutrophil CXCR1 receptors, impairing bacterial killing.

About The Cover

Cover image expansion

COVER This week features a Protocol that describes how to used engineered thioredoxin to identify redox-reactive cell surface proteins. The image is reduced recombinant human thioredoxin based on PDB 3trx. [Image: Christopher Bickel, AAAS]