Contents
Vol 2007, Issue 417
Contents
Perspective
- Studies of SARM1 Uncover Similarities Between Immune and Neuronal Responses to Danger
The adaptor protein SARM1, a member of the MyD88 family, mediates neuronal death and modulates immune responses.
Protocols
- Image Correlation Spectroscopy
The family of Image Correlation Spectroscopy techniques can be used to measure the aggregation, clustering, and dynamics of proteins in the plasma membrane.
- Identification of Redox-Active Cell-Surface Proteins by Mechanism-Based Kinetic Trapping
This procedure allows the assessment of the oxidoreductase reactivity of cell-surface proteins within their native environment.
Editors' Choice
- IP6 Got Rhythm?
The inositol kinase Ipk1, which synthesizes IP6, regulates both the length and motion of cilia.
- Bringing It All Together
Lipid binding by the Par-3 PDZ2 domain is critical to its role in epithelial polarization.
- PIKing Oncogenic Mutations
Mutations commonly associated with cancer result in disrupted interactions between the domains of a growth-related lipid kinase and alter its regulation or activity.
- TAMping Down Innate Immune Responses
TAM receptor tyrosine kinases serve in a negative feedback loop to terminate Toll-like receptor signaling in dendritic cells.
- The Pros and Cons of Acetylation
The histone acetylase CLOCK contributes to both positive and negative feedback loops in regulation of circadian gene transcription.
- Circadian Rhythm Methods
Plants and animals adjust responses to their environments through small molecules, including metabolites, that interact with their circadian clocks.
- Loss of Bactericidal Activity Promotes Infection
Excess elastase in lungs of patients with cystic fibrosis or obstructive lung disease appears to cause cleavage of neutrophil CXCR1 receptors, impairing bacterial killing.
