You are currently viewing the abstract.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Abstract
Nominations for this year's signaling breakthroughs spanned physiology, therapeutics and drug development, neuroscience, and plant signaling. Among the most exciting advances in mammalian biology were therapeutic applications of research that are overturning the conventional boundaries of signaling pathways, unexpected mechanisms to prolong life and prevent aging, new insights into schizophrenia and memory, development of a transgenic primate model, and the discovery that the cells in the lungs can “taste” noxious substances. In plant signaling, the nominations converged on the identification of the elusive receptor for the plant stress hormone abscisic acid. Finally, methodological advances were also noted with new techniques in synthetic biology enabling the precise spatiotemporal control of signaling events and increasingly facile methods for creation and analysis of proteomic data yielding tremendous increases in raw data and insights into cellular regulation.