Contents
Vol 3, Issue 104
Contents
Research Articles
- Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis
Protein O-GlcNAcylation regulates cell division.
- Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
Protein phosphorylation during the cell cycle may be an all-or-none process in many instances.
Perspective
- Cyclic Nucleotides Converge on Brown Adipose Tissue Differentiation
cGMP-mediated signaling pathways are required for the differentiation and function of brown adipocytes.
Review
- Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation
Responses to ATP play an important role in regulating the signaling and function of a diverse array of cells and tissues.
Editors' Choice
- High Fat Content
The increased abundance of the lipase MAGL and of signaling lipids in aggressive tumor cells contributes to their malignancy.
- BCR Survival Signals
Chronic active B cell receptor signaling promotes cell survival in some types of diffuse large B cell lymphomas.
- Histone Eviction During Hypoxia
Histones are removed and then replaced at the promoter of the gene encoding endothelial nitric oxide synthase in response to hypoxia.
- Recruiting the Components for Cell Division
Phosphorylation of the chromatin protein histone H2A plays a critical role in chromosome segregation during cell division.
- Cocaine Addiction and Histone Methylation
Cocaine suppression of histone methylation in the nucleus accumbens mediates the drug’s ability to enhance reward.
- Synaptic Activity of ATM and ATR
The kinases ATM and ATR associate with synaptic vesicle proteins and influence synaptic plasticity.
- A Nod to Autophagy
Bacterial invasion elicits autophagy through Nod1 and Nod2 independently of RIP2 and the NF-κB signaling pathway.
- Niche Metamorphosis
Intestinal stem cell progenitors use Notch signaling to specify a niche cell that remains undifferentiated until metamorphosis.
- Ratting Out a Diabetes Gene
Sequence variations in an adrenergic receptor gene cause reduced insulin secretion and contribute to type 2 diabetes.
- Wingless Enforces Strict Segregation
Signaling by the secreted morphogen wingless controls deposition of a myosin II–containing barrier that prevents cell mixing at segmental boundaries of the fly embryo.
