Contents
Vol 3, Issue 105
Contents
Editorial Guide
- Focus Issue: External and Internal Regulators of Immune Responses
Host defense mechanisms are modulated by host-derived and pathogen-derived factors.
Research Articles
- Distinct Signal Codes Generate Dendritic Cell Functional Plasticity
The cytokine TSLP triggers distinct signals in dendritic cells that program a T helper 2 (TH2)–type response.
- Attenuation of Rabies Virulence: Takeover by the Cytoplasmic Domain of Its Envelope Protein
Survival of rabies virus–infected neurons depends on a single amino acid in the PDZ-binding site of a viral protein.
Perspective
- TAK-ling IKK Activation: “Ub” the Judge
IL-1β-dependent activation of NF-κB occurs in two distinct stages.
Review
- What Is the Function of the Dendritic Cell Side of the Immunological Synapse?
The immunological synapse organizes signaling responses in dendritic cells as well as in T cells.
Editors' Choice
- Secretly Signaling
CXCR7 mediates ligand-induced β-arrestin signaling in the absence of G protein signaling.
- Integrin G Protein
Cell adhesion mediated by integrins is coupled to intracellular signaling by direct binding to G protein.
- Complexity at the Receptor Complex
A Wnt ligand activates one pathway and inhibits another emanating from the same receptor.
- The Smell of Aggression
The pheromone cVA promotes aggression in Drosophila through olfactory sensory neurons that express the receptor Or67d.
- Behavioral Fingerprinting
A large-scale screen of neuroactive compounds identifies pathways that may play a role in regulating rest-wake activity.
- Not Just Activated by Hypoxia
Exogenous exposure to the gas hydrogen sulfide activates HIF-1 in Caenorhabditis elegans.
- Statins for Wound Healing
By inhibiting the production of farnesyl pyrophosphate, statins may promote epithelial wound healing.
- Generator of Stomata
A secreted factor promotes the development of stomata in leaf epidermis.
Connections Map Overviews
- Interleukin-1 (IL-1) Pathway
IL-1α and IL-1β orchestrate the proinflammatory response by multiple tightly controlled mechanisms.
- Interleukin-1β (IL-1β) Processing Pathway
The NALP3 inflammasome pathway controls processing and release of interleukin-1β.
