Contents
Vol 3, Issue 106
Contents
Research Articles
- Molecular Basis of the Death-Associated Protein Kinase–Calcium/Calmodulin Regulator Complex
The structure of the death-associated protein kinase and calmodulin complex reveals how calmodulin binding leads to kinase activation.
- A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1α Activation in Pancreatic β Cells
RACK1 dictates the response of the intracellular stress sensor IRE1α to different extracellular stimuli.
Perspective
- Proteomics Modifies Our Understanding of Cell Cycle Complexity
Thousands of modified proteins were revealed in global cell cycle studies of phosphorylation and O-GlycNAcylation.
Podcast
- Science Signaling Podcast: 26 January 2010
A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence.
Editors' Choice
- Turned On by the Cold
Cold triggers a rearrangement of the cspA mRNA that promotes translation.
- Not Just a Cell Cycle Protein
Cyclin D controls gene transcription during mouse retinal development.
- Changing the Program
Kaposi’s sarcoma–associated herpesvirus reprograms infected endothelial cells by producing microRNAs that target the transcription factor c-Maf.
- Of Wnt, Prorenin Receptor, and V-ATPase
A dual-function protein acts as an adaptor in a major developmental signaling pathway.
- NK Cells Attack Pancreatic Beta Cells
The natural killer cell NKp46 receptor recognizes a ligand on pancreatic beta cells and may provide a therapeutic target against development of type 1 diabetes.
- Proline Promotes Virulence
Proline in insects triggers a change in bacteria from benign to pathogenic.
- Garnering Information on Granulomas
Epithelial cells play a role in tubercular granuloma formation and mycobacterial virulence.
- Late-Running Clock Components
Rhythmic activation of signaling occurs by core components of the biological clock mechanism.
- Making Connections
A genome-wide interaction map of yeast identifies genetic interactions, networks, and function.
- Miniature Transport Engineers
Human municipal transportation engineers might learn design strategies from the lowly slime mold.
