Contents
Vol 3, Issue 108
Contents
Research Articles
- ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway
Acetylation by ARD1 of an inhibitor of mammalian target of rapamycin may inhibit cancer growth.
- SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor
Attachment of SUMO lets insulin-like growth factor receptors act as transcriptional regulators in the nucleus.
Perspective
- Glucocorticoid Receptor DNA Binding Decoy Is a Gas
By mimicking a DNA response element, a noncoding RNA inhibits glucocorticoid receptor activity.
Editors' Choice
- Two’s Company
Transgenic mice that coexpress binding-defective and signaling-defective forms of luteinizing hormone receptor respond normally to its ligand.
- Challenging the Gβγ Paradigm
In the budding yeast Kluyveromyces lactis, the β subunit of the G protein can function without the γ subunit in the mating response.
- Do Pathogen Sensors Make You Fat?
A kinase with a role in the detection of RNA-based viruses also responds to metabolic stress.
- BMPs Rescue Regeneration
BMPs can induce redeployment of the developmental program to restore regenerative potential in the mouse digit tip.
- From PINK1 to Parkin to Mitophagy
Parkin-dependent ubiquitylation of VDAC1 links PINK1 activity to autophagy of dysfunctional mitochondria.
