16 February 2010
Vol 3, Issue 109
  • Contents

    • Research Articles

      • Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

        A high-throughput peptide array approach reveals insight into kinase substrates and specificity.

    • Podcast

    • Editors' Choice

      • How Do Muscles Know to Grow?

        A sarcolemmal fraction of the α1S subunit may act as a sensor to couple muscle activity with muscle growth.

      • Modulating Motion in the Membrane

        Depending on the activating signal, activation of phospholipase C–β2 in the plasma membrane can be localized or dispersed.

      • Branching with Ubiquitin

        The E3 ubiquitin ligase Nedd4 contributes to both dendritic and axonal branching.

      • DUBbing p53

        A deubiquitinase promotes nuclear localization of p53 in response to DNA damage.

      • Helping Out

        The neurotransmitter GABA acts in the immune system to ameliorate symptoms in a mouse model of multiple sclerosis.

      • Decoding a Second Messenger’s Message

        A bacterial signaling molecule induces the dimerization and activation of a biofilm-promoting transcription factor.

    • Connections Map Overviews

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article that describes how the pathogen Porphyromonas gingivalis, which is implicated in oral diseases such as gingivitis and periodontitis, alters crosstalk between the complement C5a receptor and Toll-like receptor 2 to disable innate immune function. [Image:]