Microbial Hijacking of Complement–Toll-Like Receptor Crosstalk

Min Wang; Jennifer L. Krauss; Hisanori Domon; Kavita B. Hosur; Shuang Liang; Paola Magotti; Martha Triantafilou; Kathy Triantafilou; John D. Lambris; George Hajishengallis

doi:10.1126/scisignal.2000697

Research ArticleHost-Pathogen Interactions

Microbial Hijacking of Complement–Toll-Like Receptor Crosstalk

Min Wang¹,
Jennifer L. Krauss¹,²,
Hisanori Domon²,
Kavita B. Hosur²,
Shuang Liang²,
Paola Magotti³,
Martha Triantafilou⁴,
Kathy Triantafilou⁴,
John D. Lambris³, and
George Hajishengallis¹,²,*

¹Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA.
²Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA.
³Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
⁴Infection and Immunity Group, University of Sussex School of Life Sciences, Falmer, Brighton, BN1 9QG, UK.

↵*To whom correspondence should be addressed. E-mail: g0haji01{at}louisville.edu

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Science Signaling 16 Feb 2010:
Vol. 3, Issue 109, pp. ra11
DOI: 10.1126/scisignal.2000697

Min Wang

1Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

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Jennifer L. Krauss

1Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

2Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA.

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Hisanori Domon

2Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA.

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Kavita B. Hosur

2Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA.

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Shuang Liang

2Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA.

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Paola Magotti

3Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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Martha Triantafilou

4Infection and Immunity Group, University of Sussex School of Life Sciences, Falmer, Brighton, BN1 9QG, UK.

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Kathy Triantafilou

4Infection and Immunity Group, University of Sussex School of Life Sciences, Falmer, Brighton, BN1 9QG, UK.

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John D. Lambris

3Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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George Hajishengallis

1Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA.

2Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA.

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For correspondence: g0haji01@louisville.edu

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