Contents
Vol 3, Issue 111
Contents
Research Articles
- Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance
Polycomb group proteins protect neurons from injury through a mechanism involving decreased potassium channel function.
- Characterization of a Domain That Transiently Converts Class 2 DYRKs into Intramolecular Tyrosine Kinases
An N-terminal region of a dual-specificity kinase temporarily enables it to phosphorylate a tyrosine rather than a serine or a threonine residue.
- Crystal Structure of the α-Kinase Domain of Dictyostelium Myosin Heavy Chain Kinase A
Structural analysis identifies features of atypical serine-threonine kinases that may account for their different activities relative to those of conventional kinases.
Perspective
- Allosteric Protein Kinase Regulation by Pseudokinases: Insights from STRAD
A kinase becomes activated when it binds as the “substrate” of a pseudokinase.
Editors' Choice
- Keeping H2O2 Where You Need It
Tyrosine phosphorylation of an H2O2-detoxifying enzyme enables localized accumulation of H2O2 involved in signal transduction.
- MHC Receptor for Retinal Circuitry
Glutamate-dependent organization of the visual input requires molecules traditionally associated with immune responses.
- Kibra Prevents Hippos
Kibra interacts with Expanded and Merlin in the Hippo pathway to control organ size.
- Legume Symbiosome
Products encoded by the leguminous plant Medicago direct the differentiation of the bacterial partner in symbiosis.
- Tripartite Toxin
A bacterial toxin targets and modifies the actin cytoskeleton in insect larvae.
- Limiting Inflammatory Signaling
The multifunctional A20 protein can act in diverse ways to limit receptor-induced inflammatory signaling.
