Contents
Vol 3, Issue 115
Contents
Research Articles
- Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling
Redox sensitivity of T cells decreases through ORAI Ca2+ channel subunit switching during T cell differentiation.
- New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion
The kinase NUAK1, which is linked to tumor invasion, promotes cell detachment by activating cytoskeletal motor proteins.
Perspective
- GPCR Dimers Fall Apart
Oligomers of G protein–coupled receptors may be less stable than previously suspected.
Review
- The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
Programmed necrosis in response to TNF requires the activity of two serine-threonine kinases.
Podcast
- Science Signaling Podcast: 30 March 2010
The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion.
Editors' Choice
- When a Channel Is Not a Channel
In fish, the calcium channel required for excitation-contraction coupling does not conduct calcium.
- Heart Cell Signaling in 3D
A change in the distribution of a signaling molecule on the surface of heart muscle cells may contribute to heart failure.
- TWEAKing Muscle Atrophy
Denervation makes muscles more responsive to the muscle-wasting cytokine TWEAK.
- Fickle Phenylalanine Mutation
A mutation in the leptin receptor causes adult-onset and diet-induced obesity in mice.
- Taking the Tube
Membranous tubular connections between natural killer cells and their targets facilitate long-distance killing.
- One Egg at a Time
Silencing of transposable elements by ARGONAUTE 9 is necessary to specify a single female gamete in Arabidopsis.
- Toothsome Signaling Parameters
Simple changes in signaling mechanisms can explain variation in tooth morphology in a wild population of seals.
- Lipid Kinase Revealed
Structural data might provide a foundation to develop specific inhibitors to a class of phosphoinositide 3-kinases.
- A Pathway to Leukemia
The self-renewing cells that drive the growth of leukemia arise, in part, through activation of a well-known cell signaling pathway.
- “Spontaneous” Release Trigger
Spontaneous synaptic vesicle fusion is triggered by soluble proteins that compete with synaptotagmins to induce membrane curvature.
