30 March 2010
Vol 3, Issue 115
  • Contents

    • Research Articles

    • Perspective

    • Review

    • Podcast

    • Editors' Choice

      • When a Channel Is Not a Channel

        In fish, the calcium channel required for excitation-contraction coupling does not conduct calcium.

      • Heart Cell Signaling in 3D

        A change in the distribution of a signaling molecule on the surface of heart muscle cells may contribute to heart failure.

      • TWEAKing Muscle Atrophy

        Denervation makes muscles more responsive to the muscle-wasting cytokine TWEAK.

      • Fickle Phenylalanine Mutation

        A mutation in the leptin receptor causes adult-onset and diet-induced obesity in mice.

      • Taking the Tube

        Membranous tubular connections between natural killer cells and their targets facilitate long-distance killing.

      • One Egg at a Time

        Silencing of transposable elements by ARGONAUTE 9 is necessary to specify a single female gamete in Arabidopsis.

      • Toothsome Signaling Parameters

        Simple changes in signaling mechanisms can explain variation in tooth morphology in a wild population of seals.

      • Lipid Kinase Revealed

        Structural data might provide a foundation to develop specific inhibitors to a class of phosphoinositide 3-kinases.

      • A Pathway to Leukemia

        The self-renewing cells that drive the growth of leukemia arise, in part, through activation of a well-known cell signaling pathway.

      • “Spontaneous” Release Trigger

        Spontaneous synaptic vesicle fusion is triggered by soluble proteins that compete with synaptotagmins to induce membrane curvature.

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing the role of the LKB1-activated kinase NUAK1 in decreasing cellular adhesion. The image shows that cells lacking NUAK1 remain attached despite treatments that cause normal cells to detach. [Image: Anna Zagórska and Alan R. Prescott, University of Dundee]