Contents
Vol 3, Issue 116
Contents
Research Articles
- Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development
CCM3, which is associated with inherited cerebrovascular defects, prevents ligand-mediated degradation of a receptor involved in blood vessel formation.
- AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay
Two ATPases regulate molecular complexes that ensure genome integrity and accurate gene expression.
- Regulation of G Protein–Coupled Receptor Signaling: Specific Dominant-Negative Effects of Melanocortin 2 Receptor Accessory Protein 2
Two homologous accessory proteins exert opposing effects on the responsiveness of the melanocortin 2 receptor to the hormone ACTH.
Perspective
- A Trojan Horse for Parkinson’s Disease
Inhibition of the kinase activity of LRRK2 may be neuroprotective.
Editors' Choice
- Determining the Flow
Planar cell polarity signaling and fluid flow regulate the orientation of cilia.
- Cytomegalovirus Immune Evasion Strategy
Cytomegalovirus monkeys can reinfect an already-infected host by evading the CD8+ T cell–mediated immune response.
- Tailor-Made Tumor
Transcriptionally different expression occurs between infected maize tissues and the corn smut infecting these tissues.
- Open and Closed Case
An occluded site stabilizes charged amino acids as they cross the membrane field to achieve a switchlike channel opening.
- Flower Power
The master transcription factor APETALA1 dynamically regulates a complex genetic network to guide flower development.
- Localized Readiness
Specific sites within the nucleus may promote maintenance of genes in a state of enhanced responsiveness.
