Research ArticleMOLECULAR BIOLOGY AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay Natsuko Izumi1, Akio Yamashita1,2,6,*, Akihiro Iwamatsu3, Rie Kurata1, Hiroki Nakamura4, Bonnie Saari5, Hisashi Hirano4, Philip Anderson5, and Shigeo Ohno1,6,*1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.2Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.3Protein Research Network Co., Ltd., Yokohama 236-0004, Japan.4International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 230-0045, Japan.5Department of Genetics, University of Wisconsin, Madison, WI 53706, USA.6Advanced Medical Research Center, Yokohama City University, Yokohama 236-0004, Japan.↵*To whom correspondence should be addressed. E-mail: ohnos{at}med.yokohama-cu.ac.jp (S.O.); yamasita{at}yokohama-cu.ac.jp (A.Y.) See allHide authors and affiliations Science Signaling 06 Apr 2010:Vol. 3, Issue 116, pp. ra27DOI: 10.1126/scisignal.2000468 Natsuko Izumi 1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Akio Yamashita 1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.2Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.6Advanced Medical Research Center, Yokohama City University, Yokohama 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: ohnos@med.yokohama-cu.ac.jp yamasita@yokohama-cu.ac.jp Akihiro Iwamatsu 3Protein Research Network Co., Ltd., Yokohama 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Rie Kurata 1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Hiroki Nakamura 4International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 230-0045, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Bonnie Saari 5Department of Genetics, University of Wisconsin, Madison, WI 53706, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Hisashi Hirano 4International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 230-0045, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Philip Anderson 5Department of Genetics, University of Wisconsin, Madison, WI 53706, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Shigeo Ohno 1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.6Advanced Medical Research Center, Yokohama City University, Yokohama 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: ohnos@med.yokohama-cu.ac.jp yamasita@yokohama-cu.ac.jp Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 3 no. 116 ra27 DOI: https://doi.org/10.1126/scisignal.2000468 PubMed: 20371770 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received June 16, 2009Accepted March 19, 2010 . Copyright & Usage: Copyright © 2010, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: April 2010 to April 2021 AbstractFullPdf Apr 2010521211205 May 20101306755 Jun 2010684628 Jul 2010684938 Aug 20101672431 Sep 20101943342 Oct 20101361428 Nov 2010791910 Dec 2010591018 Jan 2011832225 Feb 201167919 Mar 2011991527 Apr 2011691022 May 2011801921 Jun 2011901019 Jul 2011761220 Aug 2011431421 Sep 2011641817 Oct 2011472118 Nov 2011432021 Dec 2011502227 Jan 2012651012 Feb 2012491013 Mar 2012721011 Apr 201262919 May 2012421413 Jun 2012841934 Jul 2012841332 Aug 201257812 Sep 2012651320 Oct 2012582018 Nov 2012351511 Dec 201228125 Jan 2013512621 Feb 201334249 Mar 2013541421 Apr 201337169 May 2013431311 Jun 201346179 Jul 2013401912 Aug 2013381411 Sep 2013382821 Oct 2013352114 Nov 201374199 Dec 2013671512 Jan 2014481511 Feb 2014571917 Mar 2014462017 Apr 2014511315 May 2014601927 Jun 2014571611 Jul 2014441915 Aug 201428237 Sep 2014172010 Oct 20142188 Nov 2014251010 Dec 20141454 Jan 201517137 Feb 201519106 Mar 2015451810 Apr 2015261110 May 2015252213 Jun 201537711 Jul 201554133 Aug 201521016 Sep 20157838 Oct 20157912 Nov 201512331 Dec 20152126 Jan 20165676 Feb 20163567 Mar 201659911 Apr 201657424 May 2016602218 Jun 2016692411 Jul 201663163 Aug 20166655 Sep 2016592421 Oct 201667103 Nov 20166397 Dec 20163285 Jan 201754710 Feb 201744510 Mar 2017110522 Apr 201782416 May 2017108610 Jun 20175546 Jul 20175658 Aug 201763210 Sep 201747125 Oct 20177578 Nov 20175230 Dec 20173157 Jan 20186176 Feb 201873812 Mar 201849711 Apr 201814368 May 20185259 Jun 20183275 Jul 2018521313 Aug 201847106 Sep 20185387 Oct 201858146 Nov 201864145 Dec 20186478 Jan 201956237 Feb 201968116 Mar 201933169 Apr 201922107 May 201923169 Jun 201935135 Jul 2019292413 Aug 201915209 Sep 20192483 Oct 201931104 Nov 20191982 Dec 20192095 Jan 202022168 Feb 2020291810 Mar 202017129 Apr 202056219 May 202027205 Jun 202028113 Jul 20203574 Aug 202013176 Sep 202033173 Oct 202015197 Nov 20204263 Dec 202028162 Jan 202135186 Feb 20213976 Mar 202151156 Apr 20211198 View Full Text
AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay By Natsuko Izumi, Akio Yamashita, Akihiro Iwamatsu, Rie Kurata, Hiroki Nakamura, Bonnie Saari, Hisashi Hirano, Philip Anderson, Shigeo Ohno Science Signaling06 Apr 2010 : ra27 Two ATPases regulate molecular complexes that ensure genome integrity and accurate gene expression.
AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay By Natsuko Izumi, Akio Yamashita, Akihiro Iwamatsu, Rie Kurata, Hiroki Nakamura, Bonnie Saari, Hisashi Hirano, Philip Anderson, Shigeo Ohno Science Signaling06 Apr 2010 : ra27 Two ATPases regulate molecular complexes that ensure genome integrity and accurate gene expression.